Ignite Creation Date:
2024-05-05 @ 11:39 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00093847
Status:
COMPLETED
Last Update Posted:
2014-10-13
First Post:
2004-10-06
Brief Title:
Optimizing the Effectiveness of Selective Serotonin Reuptake Inhibitors SSRIs in Treatment-Resistant Depression
Sponsor:
Massachusetts General Hospital
Organization:
Massachusetts General Hospital
Study Overview
Official Title:
S-adenosyl Methionine SAMe Augmentation of Selective Serotonin Reuptake Inhibitors SSRIs for Treatment-Resistant Depression TRD
Status:
COMPLETED
Status Verified Date:
2014-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will determine the effectiveness of adding S-adenosyl methionine to antidepressant drug treatment in reducing depressive symptoms in depressed people who have not responded to antidepressants alone
Detailed Description:
Some people with depression do not respond well to antidepressant treatment S-adenosyl methionine SAMe is a naturally occurring compound that may have antidepressant effects SAMe may also enhance the effectiveness of other antidepressants such as selective serotonin reuptake inhibitors SSRIs This study will determine the effectiveness of oral SAMe in enhancing the effects of SSRIs in patients currently not responding to SSRI treatment
This study will last 6 weeks No follow-up visits will occur Participants will be randomly assigned to add either oral SAMe or placebo to their existing SSRI regimen for 6 weeks Depression scales and self-report questionnaires regarding depressive symptoms will be used to assess participants at the end of the study
This study will last 6 weeks No follow-up visits will occur Participants will be randomly assigned to add either oral SAMe or placebo to their existing SSRI regimen for 6 weeks Depression scales and self-report questionnaires regarding depressive symptoms will be used to assess participants at the end of the study
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| K23MH069629 | NIH | None | httpsreporternihgovquickSearchK23MH069629 |