Ignite Creation Date:
2024-05-06 @ 12:14 AM
Last Modification Date:
2024-10-26 @ 10:47 AM
Study NCT ID:
NCT01529970
Status:
UNKNOWN
Last Update Posted:
2012-02-09
First Post:
2012-02-07
Brief Title:
Genetic Study in Young Onset Parkinsons Disease
Sponsor:
China Medical University Hospital
Organization:
China Medical University Hospital
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2012-02
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Parkinsons disease PD is the second most frequent neurodegenerative disorder after Alzheimers disease It causes motor dysfunctions such as bradykinesia resting tremor rigidity and postural instability Although PD appears to be sporadic in most cases several causative genes and susceptibility factors have been identified that cause familial forms of the disease with Mendelian inheritance with autosomal dominant or autosomal recessive inheritance
Approximately 510 of patients with the clinical picture of PD carry a mutation in one of the known genes that cause monogenic forms of the disorder The average age at onset is between 60 and 80 years and the average age of diagnosis is 60 years Onset of primary parkinsonism before 50 years is known as early onset parkinsonismEOP Onset between 20 and 50 years is known as young-onset PD Onset at younger than 20 years is known as juvenile parkinsonism JP At least 13 loci and 9 genes are reported The investigators study is aimed to screen the clinical diagnosed familial EOP for the common mutation site by PCRDNA sequencing The gene for screen are Parkin pattern PARK2 PINK1 pattern PARK6 and ATP13A2 pattern PARK9
Approximately 510 of patients with the clinical picture of PD carry a mutation in one of the known genes that cause monogenic forms of the disorder The average age at onset is between 60 and 80 years and the average age of diagnosis is 60 years Onset of primary parkinsonism before 50 years is known as early onset parkinsonismEOP Onset between 20 and 50 years is known as young-onset PD Onset at younger than 20 years is known as juvenile parkinsonism JP At least 13 loci and 9 genes are reported The investigators study is aimed to screen the clinical diagnosed familial EOP for the common mutation site by PCRDNA sequencing The gene for screen are Parkin pattern PARK2 PINK1 pattern PARK6 and ATP13A2 pattern PARK9
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None