Ignite Creation Date:
2024-05-06 @ 12:14 AM
Last Modification Date:
2024-10-26 @ 10:46 AM
Study NCT ID:
NCT01522469
Status:
COMPLETED
Last Update Posted:
2024-01-30
First Post:
2012-01-30
Brief Title:
Phase II Study of Crenolanib in Subjects With RelapsedRefractory AML With FLT3 Activating Mutations
Sponsor:
Arog Pharmaceuticals Inc
Organization:
Arog Pharmaceuticals Inc
Study Overview
Official Title:
A Phase II Study of Crenolanib Besylate in Subjects With RelapsedRefractory Acute Myeloid Leukemia With FLT3 Activating Mutations
Status:
COMPLETED
Status Verified Date:
2024-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a Phase II open label study of crenolanib besylate This study will enroll subjects with relapsed or refractory AML with FLT3 activating mutations Prior treatment with other FLT3 TKIs is allowed Subjects will take crenolanib 200mgm2day divided in three doses daily preferably every eight hours taken orally at least 30 minutes pre or post meal until disease progression death or the patient discontinues treatment for adverse events investigators judgment or other reasons Patients who are able to proceed to allogeneic stem cell transplant will be able to resume crenolanib therapy post-transplant in an attempt to maintain remission
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None