Ignite Creation Date:
2024-05-05 @ 11:39 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00097058
Status:
COMPLETED
Last Update Posted:
2014-11-19
First Post:
2004-11-17
Brief Title:
Estrogen Use in Protection From Cognitive Decline
Sponsor:
Stanford University
Organization:
Stanford University
Study Overview
Official Title:
Estrogen Use in Protection From Cognitive Decline
Status:
COMPLETED
Status Verified Date:
2014-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study is designed to assess the effects of estrogen therapy among postmenopausal women at risk for cognitive decline
Detailed Description:
A total of 71 postmenopausal women ages 50-65 on estrogen therapy will be randomized to continue or discontinue use of estrogen and will be followed for two years
Participants will undergo PET and MRI scans and neuropsychological assessments initially and at the end of the two-year follow-up period These procedures will allow us to evaluate brain metabolism and cognitive performance at baseline and two years following continuation or discontinuation of estrogen therapy
We hypothesize that women who discontinue estrogen will show more evidence of decline than those who continue estrogen This project will expand current knowledge of effects of estrogen by 1 determining whether estrogen use among postmenopausal women at risk for cognitive decline is protective of brain metabolism 2 identifying early predictors for cognitive decline and 3 developing guidelines for estrogen use in postmenopausal women
Participants will undergo PET and MRI scans and neuropsychological assessments initially and at the end of the two-year follow-up period These procedures will allow us to evaluate brain metabolism and cognitive performance at baseline and two years following continuation or discontinuation of estrogen therapy
We hypothesize that women who discontinue estrogen will show more evidence of decline than those who continue estrogen This project will expand current knowledge of effects of estrogen by 1 determining whether estrogen use among postmenopausal women at risk for cognitive decline is protective of brain metabolism 2 identifying early predictors for cognitive decline and 3 developing guidelines for estrogen use in postmenopausal women
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| Grant R01 AG022008 | US NIH GrantContract | None | httpsreporternihgovquickSearchR01AG022008 |
| R01AG022008 | NIH | None | None |
| SPO 29004 | None | None | None |