Ignite Creation Date:
2024-05-06 @ 12:08 AM
Last Modification Date:
2024-10-26 @ 10:45 AM
Study NCT ID:
NCT01493128
Status:
COMPLETED
Last Update Posted:
2017-03-13
First Post:
2011-12-13
Brief Title:
Ultrastructure of Atrial Myocytes in Patients in Sinus Rhythm and With Atrial Fibrillation
Sponsor:
Norwegian University of Science and Technology
Organization:
Norwegian University of Science and Technology
Study Overview
Official Title:
Ultrastructure of Sarcolemma Immunofluorescence of Calcium Handling Proteins and Mitochondrial Function in Atrial Myocytes of Patients in Sinus Rhythm and With Atrial Fibrillation
Status:
COMPLETED
Status Verified Date:
2017-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The aim of this work is to study the prevalence of T-tubular system in left and right myocytes from patients in sinus rhythm and whether this is altered in paroxysmal and permanent atrial fibrillation Furthermore since current information is lacking on the key Ca2-handling proteins RyR NCX and SERCA-2a from patients in Atrial Fibrillation AF it will be investigated whether a regulation of these proteins could be an underlying cause of the disease Mitochondrial function will also studied
1 The investigators hypothesize that both structure of sarcolemma and localization of key Ca2-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm
2 The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm
1 The investigators hypothesize that both structure of sarcolemma and localization of key Ca2-handling proteins are altered in patients with atrial fibrillation compared with patients in sinus rhythm
2 The investigators hypothesize that mitochondrial function is altered in patients with atrial fibrillation compared with patients in sinus rhythm
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None