Ignite Creation Date:
2024-05-06 @ 12:07 AM
Last Modification Date:
2024-10-26 @ 10:45 AM
Study NCT ID:
NCT01493401
Status:
COMPLETED
Last Update Posted:
2019-12-02
First Post:
2011-12-14
Brief Title:
Urinary Urinary Nerve Growth Factor NGF as a Biomarker for Mixed Urinary Incontinence
Sponsor:
Samsung Medical Center
Organization:
Samsung Medical Center
Study Overview
Official Title:
Exploration of the Potential of Urinary Nerve Growth Factor NGF as a Biomarker for Diagnosis and Prognosis of Mixed Urinary Incontinence After Midurethral Slings
Status:
COMPLETED
Status Verified Date:
2019-11
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Female urinary incontinence UI can be caused by pure stress UI SUI pure urgency UI UUI and mixed SUI and UUI MUI Clinically it might not be that easy to separate MUI and SUI Patients might perceive urgency when they have an incompetent urethra and a full bladder
Urinary tract nerve growth factor NGFis produced by bladder urothelium and smooth muscle Increased levels of NGF have been reported in the bladder tissue and urine of patients with overactive bladder OAB
If the urinary levels of NGF differ among women with pure SUI and MUI then urinary NGF level might be a biomarker in the differential diagnosis of MUI in women
Also decreased urinary NGF level was reported in OAB patients of whom the symptoms were improved So we might expect that the remnant OAB symptom including urgency incontinence can be improved if the urinary NGF levels decrease after midurethral slings for SUI in MUI patients
We aimed to explore the value of the urinary NGF as a biomarker for differential diagnosis and as a prognostic marker for predicting the improvement of OAB symptom after midurethral slings
Urinary tract nerve growth factor NGFis produced by bladder urothelium and smooth muscle Increased levels of NGF have been reported in the bladder tissue and urine of patients with overactive bladder OAB
If the urinary levels of NGF differ among women with pure SUI and MUI then urinary NGF level might be a biomarker in the differential diagnosis of MUI in women
Also decreased urinary NGF level was reported in OAB patients of whom the symptoms were improved So we might expect that the remnant OAB symptom including urgency incontinence can be improved if the urinary NGF levels decrease after midurethral slings for SUI in MUI patients
We aimed to explore the value of the urinary NGF as a biomarker for differential diagnosis and as a prognostic marker for predicting the improvement of OAB symptom after midurethral slings
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None