Ignite Creation Date:
2024-05-05 @ 11:38 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00091754
Status:
COMPLETED
Last Update Posted:
2021-10-01
First Post:
2004-09-16
Brief Title:
Atherosclerosis Plaque and CVD in Communities
Sponsor:
The University of Texas Health Science Center Houston
Organization:
The University of Texas Health Science Center Houston
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2021-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To identify new cellular metabolic and genomic correlates of atherosclerotic plaque and early pathologic changes in the vascular wall and determine their consequences for coronary heart disease and stroke
Detailed Description:
BACKGROUND
This study draws upon the existing ARIC cohort of 15792 members aged 45-64 years at baseline in 1987-1989 who have completed four clinic exams three years apart with the last exam in 1998 The longitudinal ARIC cohort study focused on new cardiovascular disease CVD risk factors and subclinical measures of atherosclerosis through B-mode ultrasound of the carotid arteries The current study collects new and novel risk factors and performs carotid magnetic resonance imaging MRI examinations on a stratified random sample of 1200 ARIC participants with high 85th percentile carotid intimal-medial thickness IMT by ultrasound and 800 participants with 85th percentile IMT
DESIGN NARRATIVE
The study examines an informative subset of the bi-ethnic Atherosclerosis Risk in Communities ARIC cohort to identify cellular metabolic and genomic correlates of atherosclerotic plaque characteristics and of early changes in the vascular wall The longitudinal follow-up and stored DNA in ARIC will allow testing the ability of the genomic correlates of plaque characteristics to predict incident coronary heart disease and stroke One thousand two hundred individuals with high 85th percentile carotid artery wall thickness documented by B-mode ultrasound and 800 individuals sampled from the remainder of the carotid artery wall thickness distribution 85th percentile will receive a contrast-enhanced carotid MRI examination Standardized MRI measures will include carotid artery wall thickness T2 signal intensity changes and percent contrast enhancement indicative of endothelial dysfunction and for those with plaque fibrous cap thickness lipid core volume and calcification Novel cellular metabolic and genomic measures will be collected and will be related to MRI-measurable plaque characteristics In particular flow cytometry will be used to measure monocyte and platelet presentation of cytokines growth factors and adhesion molecules and cell-cell aggregation High throughput genotyping methods will be used to measure 5 to 7 polymorphic sites in each of 150 positional expressional and biologic candidate genes permitting multilocus and haplotype genomic analyses The depth and breadth of existing risk factor and lifestyle data extensive follow-up since 1986-89 and accumulation of clinical outcomes including coronary heart disease stroke and arteriosclerosis contribute additional strengths to the laboratory and MRI investigations Inferences will be made both cross-sectionally and longitudinally with a special emphasis on genotype plus environment interaction The ARIC cohort is in an ideal age range for the research because of the frequent and documented occurrence of plaque and the spectrum of clinically relevant stages from plaque initiation to mature fibrosis calcification and even erosion and near-rupture
This study draws upon the existing ARIC cohort of 15792 members aged 45-64 years at baseline in 1987-1989 who have completed four clinic exams three years apart with the last exam in 1998 The longitudinal ARIC cohort study focused on new cardiovascular disease CVD risk factors and subclinical measures of atherosclerosis through B-mode ultrasound of the carotid arteries The current study collects new and novel risk factors and performs carotid magnetic resonance imaging MRI examinations on a stratified random sample of 1200 ARIC participants with high 85th percentile carotid intimal-medial thickness IMT by ultrasound and 800 participants with 85th percentile IMT
DESIGN NARRATIVE
The study examines an informative subset of the bi-ethnic Atherosclerosis Risk in Communities ARIC cohort to identify cellular metabolic and genomic correlates of atherosclerotic plaque characteristics and of early changes in the vascular wall The longitudinal follow-up and stored DNA in ARIC will allow testing the ability of the genomic correlates of plaque characteristics to predict incident coronary heart disease and stroke One thousand two hundred individuals with high 85th percentile carotid artery wall thickness documented by B-mode ultrasound and 800 individuals sampled from the remainder of the carotid artery wall thickness distribution 85th percentile will receive a contrast-enhanced carotid MRI examination Standardized MRI measures will include carotid artery wall thickness T2 signal intensity changes and percent contrast enhancement indicative of endothelial dysfunction and for those with plaque fibrous cap thickness lipid core volume and calcification Novel cellular metabolic and genomic measures will be collected and will be related to MRI-measurable plaque characteristics In particular flow cytometry will be used to measure monocyte and platelet presentation of cytokines growth factors and adhesion molecules and cell-cell aggregation High throughput genotyping methods will be used to measure 5 to 7 polymorphic sites in each of 150 positional expressional and biologic candidate genes permitting multilocus and haplotype genomic analyses The depth and breadth of existing risk factor and lifestyle data extensive follow-up since 1986-89 and accumulation of clinical outcomes including coronary heart disease stroke and arteriosclerosis contribute additional strengths to the laboratory and MRI investigations Inferences will be made both cross-sectionally and longitudinally with a special emphasis on genotype plus environment interaction The ARIC cohort is in an ideal age range for the research because of the frequent and documented occurrence of plaque and the spectrum of clinically relevant stages from plaque initiation to mature fibrosis calcification and even erosion and near-rupture
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 5U01HL075572-04 | NIH | None | httpsreporternihgovquickSearch5U01HL075572-04 |