Ignite Creation Date:
2024-05-05 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00091468
Status:
UNKNOWN
Last Update Posted:
2008-01-15
First Post:
2004-09-09
Brief Title:
Nicotine Treatment of Mild Cognitive Impairment MCI
Sponsor:
National Institute on Aging NIA
Organization:
National Institute on Aging NIA
Study Overview
Official Title:
Double-Blind Treatment of Mild Cognitive Impairment MCI With Transdermal Nicotine or Transdermal Placebo
Status:
UNKNOWN
Status Verified Date:
2008-01
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this 12-month study is to determine whether nicotine administered in the form of nicotine patches can improve symptoms of memory loss in some people experiencing mild memory problems referred to in this study as mild cognitive impairment or MCI
Detailed Description:
The purpose of this study is to determine whether nicotine can improve symptoms of memory loss in some people experiencing mild memory problems referred to in this study as mild cognitive impairment or MCI The study will last approximately 12 months and will be conducted at 3 clinical sites in the United States
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain This chemical substance acetylcholine is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our mood In MCI and Alzheimers disease the level of acetylcholine may be changed and this may impair brain functioning Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimers disease Nicotine imitates many of the actions of acetylcholine By administering nicotine over a longer period of time to patients with MCI this study could lead to a better understanding of whether nicotine can act to improve memory loss symptoms over the longer term and whether it can help delay the progression of memory loss symptoms The amount of nicotine in each patch used in this study is the same level found in patches that are used in people who are trying to quit smoking
This study will include up to twelve visits
Recent studies have suggested that one of the causes of memory disorders may be a reduction in a particular chemical substance in the brain This chemical substance acetylcholine is thought to act on certain brain cells in a specific way that helps us to remember and use memories as well as affect our mood In MCI and Alzheimers disease the level of acetylcholine may be changed and this may impair brain functioning Preliminary studies have suggested that short-term administration of nicotine appears to improve memory in patients with mild memory loss and early Alzheimers disease Nicotine imitates many of the actions of acetylcholine By administering nicotine over a longer period of time to patients with MCI this study could lead to a better understanding of whether nicotine can act to improve memory loss symptoms over the longer term and whether it can help delay the progression of memory loss symptoms The amount of nicotine in each patch used in this study is the same level found in patches that are used in people who are trying to quit smoking
This study will include up to twelve visits
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AG022462-02 | NIH | None | httpsreporternihgovquickSearchR01AG022462-02 |