Ignite Creation Date:
2024-05-05 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 9:11 AM
Study NCT ID:
NCT00095407
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-11-03
Brief Title:
The Functional Anatomy of Personality Trait Knowledge An fMRI Study
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Functional Anatomy of Personality Trait Knowledge an fMRI Study
Status:
COMPLETED
Status Verified Date:
2011-12-29
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will identify the regions of the brain that are involved in personality trait knowledge-that is what a person knows about aspects of personality such as generous honest and others It will also examine brain areas relating to a persons knowledge of how likeable those personality traits are being familiar with the traits and the degree of associating such traits with ones self There has not been any previous study through modern imaging techniques on the location of the brain and the concepts of personality traits
Patients ages 21 to 65 who are in good health are right handed and native speakers of English may be eligible for this study Pregnant women are not eligible There will be 200 participants involved in pencil-and-paper or computer tasks Also there will be three functional magnetic resonance imaging fMRI experiments with 32 participants Patients may participate in up to three fMRI experiments
Patients will be recruited through NIHs Normal Control Database They would need to have had a neuroexamination conducted by an NIH doctor within the last year Patients will be interviewed for any medical neurological or psychological condition that would make it difficult to read the fMRI results Depending on the studies that patients take part in they will have different questionnaires to complete They may also perform a computerized test that measures word associations These tests will take about 1 to 2 hours
The technique of MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues During the initial MRI scan patients will lie still on a table that will slide into the enclosed tunnel of the scanner They will be in the scanner not longer than 2 hours During the procedure they may be asked to lie as still as possible for up to 1 hour at a time As the scanner takes pictures patients will hear knocking or beeping sounds and they will wear earplugs to reduce the noise Patients will be able to communicate with the MRI staff at all times during the scan and they may ask to be moved out of the machine at any time Then the functional MRI fMRI scan will involve taking pictures of the brain while patients are performing tasks All the tasks will be explained and patients will have the chance to practice them before entering the scanner For this activity patients will be asked to make decisions about what they are seeing in the tasks presented to them They will decide yes and no by pressing a left or right button This scan will take about 1 hour Afterward patients may be asked to fill out written questionnaires or to perform reaction time tasks by using a computer
This study will not have a direct benefit for participants However it is hoped that information gained will enhance researchers understanding about which areas of the brain are necessary to perform certain tasks
Patients ages 21 to 65 who are in good health are right handed and native speakers of English may be eligible for this study Pregnant women are not eligible There will be 200 participants involved in pencil-and-paper or computer tasks Also there will be three functional magnetic resonance imaging fMRI experiments with 32 participants Patients may participate in up to three fMRI experiments
Patients will be recruited through NIHs Normal Control Database They would need to have had a neuroexamination conducted by an NIH doctor within the last year Patients will be interviewed for any medical neurological or psychological condition that would make it difficult to read the fMRI results Depending on the studies that patients take part in they will have different questionnaires to complete They may also perform a computerized test that measures word associations These tests will take about 1 to 2 hours
The technique of MRI uses a strong magnetic field and radio waves to obtain images of body organs and tissues During the initial MRI scan patients will lie still on a table that will slide into the enclosed tunnel of the scanner They will be in the scanner not longer than 2 hours During the procedure they may be asked to lie as still as possible for up to 1 hour at a time As the scanner takes pictures patients will hear knocking or beeping sounds and they will wear earplugs to reduce the noise Patients will be able to communicate with the MRI staff at all times during the scan and they may ask to be moved out of the machine at any time Then the functional MRI fMRI scan will involve taking pictures of the brain while patients are performing tasks All the tasks will be explained and patients will have the chance to practice them before entering the scanner For this activity patients will be asked to make decisions about what they are seeing in the tasks presented to them They will decide yes and no by pressing a left or right button This scan will take about 1 hour Afterward patients may be asked to fill out written questionnaires or to perform reaction time tasks by using a computer
This study will not have a direct benefit for participants However it is hoped that information gained will enhance researchers understanding about which areas of the brain are necessary to perform certain tasks
Detailed Description:
Objective The purpose of the protocol is to identify the brain regions involved in personality trait knowledge associated affective valence and person-trait associations We propose using parametric event-related fMRI in addition to classical reaction time measures to answer the question of whether a specialized neural system is involved in semantic processing of personality trait concepts We will apply methods that have been used in previous investigations to identify category-specific semantic meaning systems for living and non-living objects
Study Population Healthy normal adult right-handed volunteers will be studied during functional neuroimaging and in behavioral pre-tests
Design Behavioral pre-tests N200 subjects are used to obtain psycholinguistic stimulus parameters used in the fMRI experiments Three parametric event-related functional MRI experiments for a total of 104 subjects using personality trait concept words as main input stimuli will be conducted
Outcome Measures The data collected will consist of questionnaire results behavioral measures of cognitive performance and corresponding fMRI images The results gained from this protocol will be of value in advancing the neuroscience of person perception and social cognition
Study Population Healthy normal adult right-handed volunteers will be studied during functional neuroimaging and in behavioral pre-tests
Design Behavioral pre-tests N200 subjects are used to obtain psycholinguistic stimulus parameters used in the fMRI experiments Three parametric event-related functional MRI experiments for a total of 104 subjects using personality trait concept words as main input stimuli will be conducted
Outcome Measures The data collected will consist of questionnaire results behavioral measures of cognitive performance and corresponding fMRI images The results gained from this protocol will be of value in advancing the neuroscience of person perception and social cognition
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 05-N-0018 | None | None | None |