Ignite Creation Date:
2024-05-06 @ 12:02 AM
Last Modification Date:
2024-10-26 @ 10:43 AM
Study NCT ID:
NCT01470352
Status:
COMPLETED
Last Update Posted:
2019-03-27
First Post:
2011-11-09
Brief Title:
Multiparametric MRI Study of Endogenous Analgesia and Prediction the Efficacy of Migraine Pharmacological Prevention
Sponsor:
d_yarnitsky
Organization:
Rambam Health Care Campus
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2019-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To delineate brain mechanisms that subserve EA in the healthy state and to identify alterations in mechanisms supporting EA in chronic pain and their therapeutic relevance Individuals with migraine will be examined between episodes in order to assess basal alterations in the efficiency of spatial and temporal filtering of noxious information This population provides the unique opportunity to examine such processes without confounds arising from ongoing pain
Detailed Description:
Pain is a uniquely individual experience that is powerfully shaped by the action of descending control mechanisms These systems may play crucial roles in the moment-to-moment tuning of the sensitivity spatial and temporal response characteristics of nociceptive processing mechanisms during both acute and pathological pain states However these systems remain poorly understood in human subjects The proposed research will use psychophysics and multiparametric MRI to i delineate the brain mechanisms that subserve and regulate endogenous analgesia EA in the healthy state and ii to identify alterations in mechanisms supporting EA in chronic pain and their therapeutic relevance In both healthy subjects and chronic pain patients EA will be probed using the DNIC diffuse noxious inhibitory controls and offset analgesia paradigms Functional MRI will examine activation of brainstem mechanisms important in EA while both functional and structural connectivity analyses will assess the regulation of these brainstem mechanisms by cerebral cortical regions involved in attention and affect One pathological painful condition migraine will be examined since it allows changes in EA associated with chronic pain to be investigated between episodes of pain Finally EA and EA associated structural and functional parameters will be used to predict the efficacy of one compound amitriptyline to treat migraine in individual patients Taken together the proposed research will provide substantial insights into basic mechanisms supporting and regulating EA and can provide a foundation for mechanism-based individualized choice of therapy that may benefit all chronic pain patients
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None