Ignite Creation Date:
2024-05-05 @ 11:37 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00094939
Status:
UNKNOWN
Last Update Posted:
2009-12-14
First Post:
2004-10-28
Brief Title:
Predictors of Cognitive Decline in Normal Aging
Sponsor:
National Institute on Aging NIA
Organization:
National Institute on Aging NIA
Study Overview
Official Title:
Predictors of Cognitive Decline in Normal Aging
Status:
UNKNOWN
Status Verified Date:
2009-09
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The goal of this project is to develop an early diagnostic test for Alzheimers disease AD by monitoring loss of neurons and brain size reductions over a period of five years
Detailed Description:
Studies of normal aging and mild cognitive impairment MCI show that loss of neurons and reduction in size of the hippocampal part of the brain predict a persons conversion from MCI to Alzheimers disease AD Increases in tangle-related abnormal tau proteins specifically P-tau231 also appear to be related
This study will collect neuropsychological data magnetic resonance imaging MRI and cerebrospinal fluid CSF from volunteer participants to measure the relationship between changes in brain volume CSF levels and memory performance
From the data researchers hope to develop an early diagnostic test for AD
The study will include 170 participants between the ages of 60 and 80 years some normal some with MCI some with mild AD and some with frontotemporal dementia After initial screening of volunteers the researchers will give participants a complete baseline exam and 24-month follow-up exams over a period of five years
This study will collect neuropsychological data magnetic resonance imaging MRI and cerebrospinal fluid CSF from volunteer participants to measure the relationship between changes in brain volume CSF levels and memory performance
From the data researchers hope to develop an early diagnostic test for AD
The study will include 170 participants between the ages of 60 and 80 years some normal some with MCI some with mild AD and some with frontotemporal dementia After initial screening of volunteers the researchers will give participants a complete baseline exam and 24-month follow-up exams over a period of five years
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| R01AG012101 | NIH | None | httpsreporternihgovquickSearchR01AG012101 |