Ignite Creation Date:
2024-05-06 @ 12:00 AM
Last Modification Date:
2024-10-26 @ 10:42 AM
Study NCT ID:
NCT01461603
Status:
UNKNOWN
Last Update Posted:
2016-03-03
First Post:
2011-10-19
Brief Title:
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Sponsor:
University of Aarhus
Organization:
University of Aarhus
Study Overview
Official Title:
Local Effects of Amino Acids and 3-hydroxybutyrate in the Bilaterally Perfused Human Leg
Status:
UNKNOWN
Status Verified Date:
2016-01
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Introduction Protein loss during critical illness is an important problem and is shown to predict overall survival In animal studies infusion of leucine is shown to increase the synthesis of muscle protein by 30-40 and decrease protein degradation by 30
Objectives Compared to saline an amino acid or 3hydroxybutyrate infusion in the femoral artery will promote protein synthesis and inhibit breakdown assessed with local av phenylalanine and tyrosine tracer kinetics in healthy volunteers These effects will include distinct alterations in muscle signal events in particular mTOR
Methods n 10 healthy male subjects are equipped with catheters in aa femorals and vv femorals bilaterally under local anaesthetics Each study comprises a 3-hour basal period and a 3-hour period with hyperinsulinaemic-euglycaemic clamp During the test samples of arterial and venous blood and 4 muscle biopsies are obtained The intervention contain continues saline infusion compared to either amino acids Vamin or 3hydroxybutyrate solution FFa-3OHB
Perspectives This study elucidates the direct effect of aminoacids and ketone bodies on muscle protein metabolism in humans and contribute to further development of nutritional therapy in human catabolic states
Objectives Compared to saline an amino acid or 3hydroxybutyrate infusion in the femoral artery will promote protein synthesis and inhibit breakdown assessed with local av phenylalanine and tyrosine tracer kinetics in healthy volunteers These effects will include distinct alterations in muscle signal events in particular mTOR
Methods n 10 healthy male subjects are equipped with catheters in aa femorals and vv femorals bilaterally under local anaesthetics Each study comprises a 3-hour basal period and a 3-hour period with hyperinsulinaemic-euglycaemic clamp During the test samples of arterial and venous blood and 4 muscle biopsies are obtained The intervention contain continues saline infusion compared to either amino acids Vamin or 3hydroxybutyrate solution FFa-3OHB
Perspectives This study elucidates the direct effect of aminoacids and ketone bodies on muscle protein metabolism in humans and contribute to further development of nutritional therapy in human catabolic states
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None