Ignite Creation Date:
2024-05-05 @ 11:53 PM
Last Modification Date:
2024-10-26 @ 10:41 AM
Study NCT ID:
NCT01442480
Status:
COMPLETED
Last Update Posted:
2011-09-28
First Post:
2011-09-26
Brief Title:
Cardioprotective Effects of Omega-3 Fatty Acids Supplementation in Healthy Older Subjects Exposed to Air Pollution Particles
Sponsor:
Environmental Protection Agency EPA
Organization:
Environmental Protection Agency EPA
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2011-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Exposure to ambient levels of air pollution increases cardiovascular morbidity and mortality Advanced age is among the factors associated with susceptibility to the adverse effects of air pollution Dietary fatty acid supplementation has been shown to decrease cardiovascular risk through multiple mechanisms This study evaluated the efficacy of supplementation with marine fish oil or olive oil in protecting against cardiovascular effects induced by controlled exposure of middle-aged healthy volunteers to concentrated ambient air pollution particles Subjects ages 50 to72 years were randomly assigned to receive 3 gd of fish oil 12 g eicosapentaenoic acid and 082 g docosahexaenoic acid or olive oil 3gd for 28 d Subjects were then exposed to concentrated ambient air pollution particles or filtered air for 2 hr on sequential days Heart rate variability HRV plasma lipids coagulation markers and endothelial function measured by flow-mediated dilation of the brachial artery FMD were assessed pre- immediately post- and 20 hr post-exposure
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None