Ignite Creation Date:
2024-05-05 @ 11:52 PM
Last Modification Date:
2024-10-26 @ 10:40 AM
Study NCT ID:
NCT01432028
Status:
COMPLETED
Last Update Posted:
2014-01-27
First Post:
2011-04-19
Brief Title:
Pharmacogenetic Study of Different Hormone Therapies in Recent Menopause Women
Sponsor:
Denusa Wiltgen
Organization:
Federal University of Rio Grande do Sul
Study Overview
Official Title:
Polymorphisms in Genes Encoding the Estrogen Metabolism Enzymes and Effects of Hormone Therapy for Oral Low Dose or Not Oral on Variables Related Endothelial Function Inflammation and Metabolic Profile in Patients in Recent Menopause Study Pharmacogenetic
Status:
COMPLETED
Status Verified Date:
2014-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is cross-over randomized clinical trial with objective to evaluate the effects of low-dose oral hormone therapy and non-oral hormone therapy on endothelial function markers fibrinogen von Willebrand factor c-reactive protein natriuretic peptide and on anthropometric metabolic and hormonal variables in early and healthy postmenopausal women and analyzing polymorphisms in the estrogen receptor gene and FTO polymorphisms
Patients will be randomized to receive oral hormone treatment or non-oral hormone treatment
The investigators hypothesis is that a different genotypes in the receptor estrogen gene and FTO may have an influences on treatment response in metabolic markers and cardiovascular risk
Patients will be randomized to receive oral hormone treatment or non-oral hormone treatment
The investigators hypothesis is that a different genotypes in the receptor estrogen gene and FTO may have an influences on treatment response in metabolic markers and cardiovascular risk
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None