Ignite Creation Date:
2024-05-05 @ 11:51 PM
Last Modification Date:
2024-10-26 @ 10:41 AM
Study NCT ID:
NCT01436773
Status:
COMPLETED
Last Update Posted:
2017-07-24
First Post:
2011-09-13
Brief Title:
Identification of Carotid Vasa Vasorum and Correlation With Acute Coronary Events
Sponsor:
University of Pittsburgh
Organization:
University of Pittsburgh
Study Overview
Official Title:
Identification of Carotid Vasa Vasorum and Correlation With Acute Coronary Events
Status:
COMPLETED
Status Verified Date:
2017-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Adventitial vasa vasorum VV as well as intraplaque microvessels are known to be associated with atherosclerotic plaque vulnerability Contrast-enhanced ultrasound has been validated as a technique to measure the density of VV Previous studies have demonstrated a relationship between identification of VV and relationship to vascular events such as stroke and myocardial infarction No previous study has reported the utilization of contrast-enhanced ultrasound identification of VV in the carotid bed as a means of identifying patients at high risk for acute coronary events
Aims In this study the investigators will aim to identify VV and intraplaque microvessels along with carotid intima media thickness CIMT a known marker for acute coronary events The investigators will attempt to measure the correlation of VV with acute coronary events independent of traditional cardiovascular disease CVD risk factors and CIMT
Methods 90 volunteers 30 low risk patients 30 patients with established coronary artery disease CAD and 30 patients with recent acute coronary syndrome ACS will be enrolled All patients will undergo contrast-enhanced ultrasound imaging of their carotid arteries and measurement of CIMT while obtaining baseline histories and assessment of traditional risk factors for coronary artery disease VV density and CIMT will be measured in all patients Statistical differences in VV among the three groups will be assessed and analyses will be made to attempt to identify if VV in the carotid bed is an independent predictor of acute coronary events after controlling for CIMT and traditional risk factors
Study population The study population will reflect the patient population of UPMC No individual will be excluded on the basis of race gender or ethnicity
Aims In this study the investigators will aim to identify VV and intraplaque microvessels along with carotid intima media thickness CIMT a known marker for acute coronary events The investigators will attempt to measure the correlation of VV with acute coronary events independent of traditional cardiovascular disease CVD risk factors and CIMT
Methods 90 volunteers 30 low risk patients 30 patients with established coronary artery disease CAD and 30 patients with recent acute coronary syndrome ACS will be enrolled All patients will undergo contrast-enhanced ultrasound imaging of their carotid arteries and measurement of CIMT while obtaining baseline histories and assessment of traditional risk factors for coronary artery disease VV density and CIMT will be measured in all patients Statistical differences in VV among the three groups will be assessed and analyses will be made to attempt to identify if VV in the carotid bed is an independent predictor of acute coronary events after controlling for CIMT and traditional risk factors
Study population The study population will reflect the patient population of UPMC No individual will be excluded on the basis of race gender or ethnicity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None