Ignite Creation Date:
2024-05-05 @ 11:49 PM
Last Modification Date:
2024-10-26 @ 10:40 AM
Study NCT ID:
NCT01424761
Status:
COMPLETED
Last Update Posted:
2013-06-12
First Post:
2011-08-24
Brief Title:
Coenzyme Q10 in Relation to the Antioxidative Vitamins Oxidative Stress and Inflammation in Coronary Artery Disease Patients During Statin Therapy
Sponsor:
Taichung Veterans General Hospital
Organization:
Taichung Veterans General Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2013-06
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Cardiovascular disease CVD is the leading cause of Taiwan American Heart Association AHA indicated that CVD patients with Statin therapy would decrease the recurrence of CVD The goal for lipid lowering in CVD patients was set at the level of low-density lipoprotein cholesterol LDL-C below 100 mgdL Coenzyme Q10 is recognized as a lipid soluble antioxidant Statin treatment might affect the level of coenzyme Q10 Therefore the purposes of this study are going to investigate the relation of coenzyme Q10 with other antioxidant vitamins Vitamin A and E the markers of lipid peroxidation antioxidant enzymes activities and the inflammatory markers in coronary artery disease CAD patients during Statin therapy The study is going to design a placebo-controlled study The investigators will recruit coronary artery disease CAD patients who are identified by cardiac catheterization as having at least 50 stenosis of one major coronary artery and healthy subjects CAD subjects are randomly assign to placebo and coenzyme Q10 supplements 150 mgbid 300 mgd groups Intervention is going to administration for three months Fasting blood will be obtained in each month and determine the concentration of antioxidant vitamins lipid peroxidation markers antioxidant enzymes activities after intervention Meanwhile the investigators will measure the level of inflammatory markers in all subjects of this study Hopefully the results of this study could provide information of coenzyme Q10 supplementation for clinical dietitian in advising CAD patients who are under Statin therapy
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None