Ignite Creation Date:
2025-12-25 @ 2:13 AM
Ignite Modification Date:
2025-12-26 @ 7:10 PM
Study NCT ID:
NCT04482660
Status:
ENROLLING_BY_INVITATION
Last Update Posted:
2025-05-31
First Post:
2020-07-20
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population
Sponsor:
Barcelonabeta Brain Research Center, Pasqual Maragall Foundation
Organization:
Study Overview
Official Title:
Characterization of Cerebral Tau Aggregates With 18F-RO6958948 PET in the ALFA Population
Status:
ENROLLING_BY_INVITATION
Status Verified Date:
2025-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will characterize tau tracer retention by Positron Emission Tomography (PET) as a function of amyloid levels transversally and longitudinally.
Detailed Description:
CROSS-SECTIONAL OBJECTIVES
* To measure 18F-RO6958948 retention in selected participants of ALFA-related studies as a function of amyloid levels.
* To study the relation between 18F-RO6958948 retention and amyloid levels.
* To characterize imaging correlates as a function of tau and amyloid levels.
* To study the role of tau retention on cognitive performance.
* To define predictors of tau retention.
LONGITUDINAL OBJECTIVES
* To measure tau accumulation and spreading in participants of the ALFA-related studies of BBRC as a function of baseline amyloid levels.
* To study the dynamic relation between tau spreading and amyloid levels longitudinally.
* To define predictors of tau spreading.
* To measure 18F-RO6958948 retention in selected participants of ALFA-related studies as a function of amyloid levels.
* To study the relation between 18F-RO6958948 retention and amyloid levels.
* To characterize imaging correlates as a function of tau and amyloid levels.
* To study the role of tau retention on cognitive performance.
* To define predictors of tau retention.
LONGITUDINAL OBJECTIVES
* To measure tau accumulation and spreading in participants of the ALFA-related studies of BBRC as a function of baseline amyloid levels.
* To study the dynamic relation between tau spreading and amyloid levels longitudinally.
* To define predictors of tau spreading.
Study Oversight
Has Oversight DMC:
False
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
False
Is an FDA AA801 Violation?: