Ignite Creation Date:
2024-05-05 @ 11:43 PM
Last Modification Date:
2024-10-26 @ 10:37 AM
Study NCT ID:
NCT01390688
Status:
UNKNOWN
Last Update Posted:
2011-07-11
First Post:
2011-07-05
Brief Title:
Brain-derived Neurotrophic Factor and Cogntive Function
Sponsor:
Rigshospitalet Denmark
Organization:
Rigshospitalet Denmark
Study Overview
Official Title:
Brain-derived Neurotrophic Factor A Link to Obesity Insulin Resistance and Cognitive Dysfunktion
Status:
UNKNOWN
Status Verified Date:
2009-06
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Individuals with type 2 diabetes have an increased risk of developing cognitive dysfunction followed by dementia in late life Obesity physical inactivity and systemic low-grade inflammation are strong risk factors and play a crucial role in this network of diseases
Brain-derived Neurotrophic factor BDNF is produced in brain as well as several tissues outside brain eg muscle cells Low BDNF are associated with cognitive dysfuction obesity and type 2 diabetes
The investigators include 200 individuals divided into three groups 80 individuals with type 2 diabetes 80 age and BMI-matched controls and 40 individuals with impaired glucose tolerance
The project will test the hypothesis that low systemic BDNF are associated with accumulation of abdominal fat cognitive dysfunction and insulin resistence with different effect in men and women
Brain-derived Neurotrophic factor BDNF is produced in brain as well as several tissues outside brain eg muscle cells Low BDNF are associated with cognitive dysfuction obesity and type 2 diabetes
The investigators include 200 individuals divided into three groups 80 individuals with type 2 diabetes 80 age and BMI-matched controls and 40 individuals with impaired glucose tolerance
The project will test the hypothesis that low systemic BDNF are associated with accumulation of abdominal fat cognitive dysfunction and insulin resistence with different effect in men and women
Detailed Description:
Methods
200 individuals in age 40-65 years are recruited and categorized into 3 groups 1 Type 2 Diabetes 2 Impaired glucose Tolerance and 3 Normal Glucose Tolerance Groups are supposed to be age and BMI-matched
Measurements of systemic BDNF cogntive function memory attention and langue fitness bodycomposition glucose metabolism and systemic inflammation are done
Multiple regression analysis are perfomed to explain variablity in cognitive function with age visceral fat and BDNF as explanotory varibales
200 individuals in age 40-65 years are recruited and categorized into 3 groups 1 Type 2 Diabetes 2 Impaired glucose Tolerance and 3 Normal Glucose Tolerance Groups are supposed to be age and BMI-matched
Measurements of systemic BDNF cogntive function memory attention and langue fitness bodycomposition glucose metabolism and systemic inflammation are done
Multiple regression analysis are perfomed to explain variablity in cognitive function with age visceral fat and BDNF as explanotory varibales
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None