Ignite Creation Date:
2024-05-05 @ 11:43 PM
Last Modification Date:
2024-10-26 @ 10:38 AM
Study NCT ID:
NCT01399060
Status:
COMPLETED
Last Update Posted:
2013-10-24
First Post:
2011-07-19
Brief Title:
Cough Sensitivity and Taste Preferences
Sponsor:
Monell Chemical Senses Center
Organization:
Monell Chemical Senses Center
Study Overview
Official Title:
Cough and Taste Preferences in Adolescents and Adults
Status:
COMPLETED
Status Verified Date:
2013-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
CAP
Brief Summary:
This single-site within-subject experimental study is designed to test the hypothesis children who live in a household in which one or both of their parent smoke will exhibit a higher cough threshold and will prefer more intense sweet tastes than children who live in a household where neither parent smokes Subjects will include at least 50 racially and ethnically diverse healthy children aged 10 to 17 years a critical time for experimenting with tobacco and a parent The sample will comprise two groups Non-Environmental Tobacco Smoke ETS Exposed neither the child nor parents has ever smoked or been exposed to environmental tobacco smoke ETS in the home and ETS-Exposed the parent has smoked at least 3 cigarettes per day for at least five years in the home with the child living in the home continuously Cough sensitivity will be measured using a standard single-inhalation challenge a test of the minimum concentration of capsaicin the spicy chemical in hot peppers needed to elicit cough Sweet taste preferences will be measured using a forced-choice paired comparison method of liquids which differ in sucrose content Measures of breath carbon monoxide will validate the smoking status of parents and their adolescent children The key comparison will be between Non-ETS Exposed and ETS-Exposed children with the difference between smoking and non-smoking parents as a positive control Because smoking and non-smoking families may differ in ways besides tobacco exposure the investigators will obtain health histories with a focus on respiratory illness smoking histories measures of body weight diet and responses to personality tests including susceptibility to addiction The investigators will also obtain genomic DNA from saliva samples Genes for chemosensory receptors that are part of the cough reflex pathway and genotype may account for aspects of cough sensitivity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| SAP No 4100054860 | OTHER_GRANT | Pennsylvania Department of Health | None |