Ignite Creation Date:
2024-05-05 @ 11:42 PM
Last Modification Date:
2024-10-26 @ 10:37 AM
Study NCT ID:
NCT01390142
Status:
COMPLETED
Last Update Posted:
2013-10-18
First Post:
2011-07-06
Brief Title:
Remote Ischemic Preconditioning Combined to Local Ischemic Postconditioning in Acute Myocardial Infarction
Sponsor:
University Hospital Angers
Organization:
University Hospital Angers
Study Overview
Official Title:
Remote Ischemic Preconditioning Combined to Local Ischemic Postconditioning in Acute Myocardial Infarction RIRE-1
Status:
COMPLETED
Status Verified Date:
2013-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
RIRE-1
Brief Summary:
RIRE-1 is a randomized open-label with blinded end-point study that will test the hypothesis that remote ischemic preconditioning initiated at the time of the admission in the cathlab reduces infarct size in ST-segment elevation myocardial infarction STEMI patients treated with percutaneous coronary intervention PCI Furthermore it will determine whether a combined approach remote ischemic preconditioning and local ischemic postconditioning can further reduce infarct size Infarct size will be determined by cardiac magnetic resonance imaging at 3-month follow-up and with 72 hours area under curve of CK-MB
Detailed Description:
In the management of STEMI prompt reperfusion of the jeopardized myocardium is the most effective way to limit infarct size which is a major determinant of morbidity and mortality However restoration of blood flow may paradoxically have deleterious consequences and lead to lethal myocardial ischemia-reperfusion injury Local ischemic postconditioning IPost and remote ischemic preconditioning RIPer are promising methods to decrease ischemia-reperfusion injury
The hypothesis tested in this research proposal is that RIPer initiated at the time of the admission in the cathlab reduces infarct size in STEMI patients treated with PCI Furthermore the investigators will determine whether a combined approach RIPer IPost can further reduce infarct size
The hypothesis tested in this research proposal is that RIPer initiated at the time of the admission in the cathlab reduces infarct size in STEMI patients treated with PCI Furthermore the investigators will determine whether a combined approach RIPer IPost can further reduce infarct size
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None