Ignite Creation Date:
2025-12-25 @ 2:09 AM
Ignite Modification Date:
2025-12-26 @ 4:29 AM
Study NCT ID:
NCT00465660
Status:
UNKNOWN
Last Update Posted:
2007-04-25
First Post:
2007-04-24
Is NOT Gene Therapy:
True
Has Adverse Events:
False
Brief Title:
Resistive Exercise for Arthritic Cartilage Health (REACH)
Sponsor:
University of Sydney
Organization:
Study Overview
Official Title:
The Effect of 6 Month High Intensity Progressive Resistance Training on Knee Articular Cartilage Morphology in Female Osteoarthritic Patients
Status:
UNKNOWN
Status Verified Date:
2006-12
Last Known Status:
ACTIVE_NOT_RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Female subjects over the age of 40 will be recruited and randomised into a progressive resistance training (PRT) or sham-exercise group. The PRT group will train at 80% of their peak strength, using Keiser pneumatic resistance machines, and progress approximately 3% per session. Strength will be re-assessed fortnightly. Exercises will target muscles around the hip and knee. The sham-exercise group will train on the same equipment as the PRT group except hip adduction, but without added resistance or progression. Both groups will train 3 days per week for roughly 45 minutes for 6 months.
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.
Primary Outcome:
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes:
Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, \& post) Medications (pre, 3 months, \& post) Body composition (pre, 3 months, \& post) Balance; Physical function (pre, 3 months, \& post) Questionnaires (pre, 3 months, \& post)
* Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
* Depressive symptoms (Depression Scale) -Quality of life (SF36)
* Confidence performing physical activity (Ewart) -Demographics
It is hypothesised that high intensity PRT will decelerate the tibial and femoral cartilage degeneration in the knee affected most by OA.
Primary Outcome:
Articular cartilage morphology following 6 months high intensity progressive resistance training
Secondary Outcomes:
Muscle and fat cross-sectional area (CSA) (pre and post) Muscle strength, power, endurance, and contraction velocity (pre, 3 months, \& post) Medications (pre, 3 months, \& post) Body composition (pre, 3 months, \& post) Balance; Physical function (pre, 3 months, \& post) Questionnaires (pre, 3 months, \& post)
* Habitual exercise (PASE) -WOMAC index (pain, stiffness and functional ability)
* Depressive symptoms (Depression Scale) -Quality of life (SF36)
* Confidence performing physical activity (Ewart) -Demographics
Detailed Description:
None
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: