Ignite Creation Date:
2024-05-05 @ 11:33 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01352923
Status:
WITHDRAWN
Last Update Posted:
2024-06-28
First Post:
2011-05-11
Brief Title:
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations
Sponsor:
Universitaire Ziekenhuizen KU Leuven
Organization:
Universitaire Ziekenhuizen KU Leuven
Study Overview
Official Title:
Study of Polymorphisms in pear1 Gene Link to Platelet Activation and Signaling Pathway Variations
Status:
WITHDRAWN
Status Verified Date:
2011-05
Last Known Status:
Recruiting
Delayed Posting:
No
If Stopped, Why?:
no resources
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
In this study PEAR1 polymorphisms effects will be analyze in blood platelets to determine how PEAR1 regulates platelet activation
Detailed Description:
Several large-scale studies have confirmed the long held notion that platelet responses to different agonists are highly variable within well defined populations of healthy donors Single nucleotide polymorphisms in genes encoding platelet proteins can explain the wide range of responses to standard platelet agonists Yet numerous SNPs point towards proteins with previously unknown function in platelets wich modulate the complex network of signaling events that regulate platelet function and further augment variability PEAR1 is mainly expressed in platelets and endothelial cells A few studies have linked SNPs in PEAR1 with decreased or increased platelet responses to various agonists However hitherto no direct functional studies have been carried out to determine whether and how PEAR1 modulate intracellular signaling pathways relevant for platelet function
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None