Ignite Creation Date:
2024-05-05 @ 11:34 AM
Last Modification Date:
2024-10-26 @ 9:10 AM
Study NCT ID:
NCT00081419
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-04-10
Brief Title:
Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Timing of Voluntary Movement in Patients With Tourette Syndrome and Chronic Tic Disorder Using EEG and Surface EMG
Status:
COMPLETED
Status Verified Date:
2009-01-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the brain controls movement in people with Tourette syndrome and chronic tic disorder to determine if the timing of movement is important in whether someone feels in control of their movements Although movements in tic disorders are often characterized as involuntary some patients claim that these movements are made voluntarily or they are unable to decide if they are voluntary or involuntary Previous experiments have shown that when people are asked to look at a clock and report the time they first decide to make a movement they report times later than the first brain waves associated with movement appear When they are asked to report the time they first initiate the movement they report times before the muscles actually begin to move This study may help determine how the sense of willing and initiating an action is altered in patients with Tourette syndrome and chronic tic disorder and how people may feel more or less in control of their movements
Normal volunteers and patients with Tourette syndrome or chronic tic disorder between 18 and 65 years of age may be eligible for this study Control subjects must not have any neurological or psychological disorders and patients with Tourette syndrome of chronic tic disorder must not have any other neurological disorders Patients with attention deficit hyperactivity disorder ADHD may not enroll in this study
All participants will have a medical history physical examination and a test to determine their level of attention Patients will be interviewed about their symptoms and complete psychiatric rating scales In addition all participants will undergo the following procedures
Electric shock
Participants look at a clock on a computer screen the hands of which revolves quickly While looking at the clock each participant will be given small non-painful electric shocks and asked according to the clock to say when they received the shocks The shocks are repeated 40 times
Arm movement
Participants are asked to lift their arms off a table repeatedly at random times while they look at the computer clock This exercise is repeated 80 times Of these 80 participants are asked 10 times consecutively to say the time they first had the desire to move their arm and then 10 consecutively the time they first felt that they were moving their arm
Electroencephalography EEG and Electromyography EMG
Participants undergo EEG and EMG durin
Normal volunteers and patients with Tourette syndrome or chronic tic disorder between 18 and 65 years of age may be eligible for this study Control subjects must not have any neurological or psychological disorders and patients with Tourette syndrome of chronic tic disorder must not have any other neurological disorders Patients with attention deficit hyperactivity disorder ADHD may not enroll in this study
All participants will have a medical history physical examination and a test to determine their level of attention Patients will be interviewed about their symptoms and complete psychiatric rating scales In addition all participants will undergo the following procedures
Electric shock
Participants look at a clock on a computer screen the hands of which revolves quickly While looking at the clock each participant will be given small non-painful electric shocks and asked according to the clock to say when they received the shocks The shocks are repeated 40 times
Arm movement
Participants are asked to lift their arms off a table repeatedly at random times while they look at the computer clock This exercise is repeated 80 times Of these 80 participants are asked 10 times consecutively to say the time they first had the desire to move their arm and then 10 consecutively the time they first felt that they were moving their arm
Electroencephalography EEG and Electromyography EMG
Participants undergo EEG and EMG durin
Detailed Description:
OBJECTIVES The purpose of this study is to determine how the subjective sense of willing and initiating an action is altered in patients with Tourette Syndrome and Chronic Tic Disorder Although many definitions of the disease include the characterization of tics as involuntary some patients claim that these movements are voluntarily made or are unable to decide if they are voluntary or involuntary Recent studies have shown that the time order in which someone wills a voluntary movement and begins that movement is central to the subjective sense of causality We propose to examine tics as well as normal voluntary movements in patients with Tourette Syndrome and Chronic Tic Disorder to identify the time course between the decision to move and the onset of movement Using Libets paradigm we intend to have subjects watch a fast-rotating clock to report the times associated with willing time W and initiating time M movement we will also determine electroencephalographicelectromyographic EEGEMG measures of movement
STUDY POPULATION We intend to study adult patients with a Diagnostic and Statistical Manual of Mental Disorders diagnosis of a tic disorder and frequent tics as well as normal healthy volunteers as controls
DESIGN We will ask tic patients to rate the voluntariness of their tics using a rating scale We will ask tics patients to look at a fast-rotating clock on a computer screen and note when their movements were willed time W and were initiated time M for tics as well as normal voluntary movements Patients will also report the time of a somatosensory stimulus Surface EMG will determine the time of actual movement and EEG will record brain potentials associated with movement The design will be the same for the normal volunteers with the exception that the volunteers will not complete rating scales and will not be experiencing tics
OUTCOME MEASURES The primary outcome measure of this study is the latency of times W and M before EMG onset in tics patients as correlated with the voluntariness the patients associate with their tics compared to the time W and M reported for normal voluntary movements in the normal volunteers
STUDY POPULATION We intend to study adult patients with a Diagnostic and Statistical Manual of Mental Disorders diagnosis of a tic disorder and frequent tics as well as normal healthy volunteers as controls
DESIGN We will ask tic patients to rate the voluntariness of their tics using a rating scale We will ask tics patients to look at a fast-rotating clock on a computer screen and note when their movements were willed time W and were initiated time M for tics as well as normal voluntary movements Patients will also report the time of a somatosensory stimulus Surface EMG will determine the time of actual movement and EEG will record brain potentials associated with movement The design will be the same for the normal volunteers with the exception that the volunteers will not complete rating scales and will not be experiencing tics
OUTCOME MEASURES The primary outcome measure of this study is the latency of times W and M before EMG onset in tics patients as correlated with the voluntariness the patients associate with their tics compared to the time W and M reported for normal voluntary movements in the normal volunteers
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0153 | None | None | None |