Ignite Creation Date:
2024-05-05 @ 11:33 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01358617
Status:
COMPLETED
Last Update Posted:
2015-05-12
First Post:
2011-05-19
Brief Title:
Prognostic Biomarkers in Tumor Tissue Samples From Young Patients With Neuroblastoma
Sponsor:
Childrens Oncology Group
Organization:
Childrens Oncology Group
Study Overview
Official Title:
Observational - Expression of Ubiquitin Carboxyl-Terminal Hydrolase 1 UCHL1 in Neuroblastoma Cancer Stem Cells and Its Relationship to Patient Prognosis
Status:
COMPLETED
Status Verified Date:
2015-05
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This research study is studying biomarkers in tumor tissue samples from young patients with neuroblastoma Studying samples of tissue from patients with cancer in the laboratory may help doctors identify biomarkers and learn more about biomarkers related to cancer
Detailed Description:
PRIMARY OBJECTIVES
I Determine whether ubiquitin carboxyl-terminal hydrolase 1 UCHL1 expression is an indirect cancer stem cell marker in pediatric patients with neuroblastoma Correlate UCHL1 expression with staging information and patients outcome
Study Subtype Observational Observational Study Model Case-control Time Perspective Retrospective Biospecimen Retention None Retained Biospecimen Description Tissue Study Population Description Tissue microarray samples from patients with Neuroblastoma supplied by the COG Biopathology Center Sampling Method Probability
OUTLINE
Archived tissue microarray samples are analyzed for ubiquitin carboxyl-terminal hydrolase 1 UCHL1 expression by UCHL1 monoclonal antibody and peroxidase technique Results are then compared with patients clinical data including age at diagnosis race date of diagnosis histology stage and location at diagnosis presence of cancer predisposition date of completion of treatment surgery performed type of chemotherapy received history of recurrence and status alive with disease alive without disease dead if available
I Determine whether ubiquitin carboxyl-terminal hydrolase 1 UCHL1 expression is an indirect cancer stem cell marker in pediatric patients with neuroblastoma Correlate UCHL1 expression with staging information and patients outcome
Study Subtype Observational Observational Study Model Case-control Time Perspective Retrospective Biospecimen Retention None Retained Biospecimen Description Tissue Study Population Description Tissue microarray samples from patients with Neuroblastoma supplied by the COG Biopathology Center Sampling Method Probability
OUTLINE
Archived tissue microarray samples are analyzed for ubiquitin carboxyl-terminal hydrolase 1 UCHL1 expression by UCHL1 monoclonal antibody and peroxidase technique Results are then compared with patients clinical data including age at diagnosis race date of diagnosis histology stage and location at diagnosis presence of cancer predisposition date of completion of treatment surgery performed type of chemotherapy received history of recurrence and status alive with disease alive without disease dead if available
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| NCI-2011-02856 | REGISTRY | None | None |
| U10CA098543 | NIH | CTRP Clinical Trial Reporting Program | httpsreporternihgovquickSearchU10CA098543 |