Ignite Creation Date:
2024-05-05 @ 11:33 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01352026
Status:
WITHDRAWN
Last Update Posted:
2012-08-06
First Post:
2011-05-10
Brief Title:
Evaluation of Metformin Activity in Addition to Conventional Treatment of Grade II or III Pulmonary Arterial Hypertension PAH
Sponsor:
Nantes University Hospital
Organization:
Nantes University Hospital
Study Overview
Official Title:
None
Status:
WITHDRAWN
Status Verified Date:
2012-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Several therapeutic have been developed making more difficult the eligibility of patients - Recruitment of new centers wasnt possible due to competing trials
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
MetHTAP
Brief Summary:
Treatment of PAH includes exercise limitation non specific agents anticoagulants diuretics and supplemental oxygen pulmonary specific vasodilators and antiproliferative agents
Recent data obtained by our group within rat PAH models showed that the antihyperglycemic drug metformin used in France since 1959 in diabetic type II patients significantly acts at the pulmonary arteries level
According to these results and knowing that metformin is a widely used drug with a favorable safety profile the investigators decided to set up a pilot study in order to evaluate the activity of metformin in PAH treatment In parallel the investigators will focus on metformin mechanism of action
Recent data obtained by our group within rat PAH models showed that the antihyperglycemic drug metformin used in France since 1959 in diabetic type II patients significantly acts at the pulmonary arteries level
According to these results and knowing that metformin is a widely used drug with a favorable safety profile the investigators decided to set up a pilot study in order to evaluate the activity of metformin in PAH treatment In parallel the investigators will focus on metformin mechanism of action
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None