Ignite Creation Date:
2024-05-05 @ 11:32 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01353547
Status:
RECRUITING
Last Update Posted:
2022-09-19
First Post:
2011-05-11
Brief Title:
Genes and Environment in Multiple Sclerosis
Sponsor:
Columbia University
Organization:
Columbia University
Study Overview
Official Title:
Integrating Genetic and Environmental Risk Scores Into an Algorithm to Predict Multiple Sclerosis Susceptibility
Status:
RECRUITING
Status Verified Date:
2022-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
GEMS
Brief Summary:
The purpose of the research study is to identify the genetic environmental and immune profiles that may increase a persons risk of developing multiple sclerosis MS While MS is not a disease caused by a single variation in genetic material DNA a single environmental factor or a single malfunction in immune cells there are genetic alterations environmental exposures and immunologic factors that make the development of MS more likely Obtaining information about who is at risk for MS will be beneficial in the future if the investigators can identify effective ways to prevent or slow down the progression of this disease
Detailed Description:
MS is an autoimmune disease in which the immune system white bloods cells that normally fight infection becomes misdirected and attacks healthy tissue In patients with MS the misdirected white blood cells attack myelin a lining that insulates the nerves found in the brain and spinal cord This results in inflammation and damage in the myelin Loss of this protective lining disrupts nerve impulses and causes abnormal function in the nervous system
This large research study will ultimately enroll 5000 subjects who are at risk of developing MS
This large research study will ultimately enroll 5000 subjects who are at risk of developing MS
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
False
Is a FDA Regulated Device?:
False
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
True
Is an FDA AA801 Violation?:
None