Ignite Creation Date:
2024-05-05 @ 11:32 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01356836
Status:
COMPLETED
Last Update Posted:
2011-05-20
First Post:
2011-05-17
Brief Title:
The Association Between Different Monocyte Subsets and Coronary Collateral Development
Sponsor:
Yuksek Ihtisas Hospital
Organization:
Yuksek Ihtisas Hospital
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2011-03
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Collateral growth and coronary angiogenesis are chronic adaptations to myocardial ischemia Collateralization helps to restore blood flow and as a result salvages myocardium in severely ischemic myocardial regions Thus good collateral development in patients with severe coronary artery disease CAD improves ventricular function and prognosis 1-3
However coronary collateral development is different among patients even with similar degrees of coronary artery stenosis Several factors such as diabetes mellitus 4 and duration of myocardial ischemic symptoms 5 have been reported to effect coronary collateral development At the cellular level inflammatory cells especially monocytes have an important role in collateralization In a series of experimental studies with animals it has been shown that monocytes are important elements for development of collateral vessels 6-7 In a recent study it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease 8
Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 9 CD14CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor and CD14CD16 monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor These subsets differ in function and response to several cytokines
Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development
However coronary collateral development is different among patients even with similar degrees of coronary artery stenosis Several factors such as diabetes mellitus 4 and duration of myocardial ischemic symptoms 5 have been reported to effect coronary collateral development At the cellular level inflammatory cells especially monocytes have an important role in collateralization In a series of experimental studies with animals it has been shown that monocytes are important elements for development of collateral vessels 6-7 In a recent study it has been demonstrated that increased circulating monocyte count is related to good collateral development in patients with stable coronary artery disease 8
Monocytes in human blood are heterogeneous and can be classified into two subsets according to the presence or absence of the FcγRIII receptor CD16 9 CD14CD16- monocytes characterized by high level expression of the CD14 cell surface receptor but no expression of CD16 receptor and CD14CD16 monocytes characterized by the co-expression of CD16 receptor with either high or low level expression of the CD14 receptor These subsets differ in function and response to several cytokines
Our aim in this study was to find out any possible relationship between the levels of circulating monocyte subsets and coronary collateral development
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None