Ignite Creation Date:
2024-05-05 @ 11:31 PM
Last Modification Date:
2024-10-26 @ 10:35 AM
Study NCT ID:
NCT01351012
Status:
COMPLETED
Last Update Posted:
2014-02-19
First Post:
2011-03-14
Brief Title:
Canola Oil Multicentre Intervention Trial
Sponsor:
University of Manitoba
Organization:
University of Manitoba
Study Overview
Official Title:
Canola and Flax Oils in Modulation of Vascular Function and Biomarkers of Cardiovascular Disease Risk
Status:
COMPLETED
Status Verified Date:
2014-02
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
COMIT
Brief Summary:
The purpose of the study is to examine how the consumption of different dietary oil varieties affects a broad range of metabolic responses that are important in the development of cardiovascular diseases This study will examine the relationship between dietary oil consumption and arterial function blood fat content and blood markers of cardiovascular disease risk Additionally the efficiency of the body in converting fat from dietary oils into other specific fat compounds with know health benefits will be examined Also the correlation between psychosocial parameters and vascular function will be studied
Detailed Description:
Although consumption of omega-3 fatty acids favorably modulate circulating lipids and arterial health there is confusion surrounding the specific health benefits of plant based alpha-linolenic acid ALA versus marine derived eicosapentaenoic acid EPA and docosahexaenoic acid DHA This research will examine the health benefits of ALA from consumption of diets rich in canola oil novel monounsaturated fatty acid MUFA and DHA enriched canola oils and flax oil compared with a control diet representative of North American diets rich in omega-6 and saturated fats Treatment oils will be examined for potential influence on endothelial dysfunction inflammation oxidation body composition and plasma lipoprotein characterization Furthermore in an effort to elucidate the genetic factors that promote ALA conversion to EPADHA and strengthen the role of ALA in cardiovascular health a major objective is to correlate common genetic variants in the fatty acid desaturase 1 FADS1 and fatty acid desaturase 2 FADS2 gene cluster with ALA conversion to EPADHA and n-3 fatty acid composition of serum phospholipids in response to consumption of the treatment oils Besides psychosocial predictors of vascular function will be investigated
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None