Ignite Creation Date:
2024-05-05 @ 11:34 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00072956
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
2003-11-12
Brief Title:
The Physiology of Tricks
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
The Physiology of Tricks
Status:
COMPLETED
Status Verified Date:
2005-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine the action of sensory tricks on an occurrence known as surround inhibition when there is a disorder of muscle tone affecting a single body part in isolation Surround inhibition refers to a situation that suppresses unwanted movements known as dystonia in surrounding muscles during voluntary actions There are tricks-various actions-that people use to temporarily stop those unwanted movements Such tricks can include touching the affected body part placing an object in the mouth pulling the hair and others Often these tricks are beneficial early in the illness but become less effective as it progresses This study is guided by a hypothesis that sensory tricks will restore surround inhibition and by another hypothesis that it is the application of the tricks not simply sensory input that is effective in doing that restoring Emphasis is on cervical dystonia involuntary actions affecting the neck in which the tricks commonly involve the cheeks and chin The technique used in the study is transcranial magnetic stimulation TMS
Patients ages 18 and older who have cervical dystonia with at least one effective trick and patients with no effective trick may be eligible for this study There will also be a control group of healthy participants
Participants will be asked to show the sensory trick and may be asked to be videotaped During the TMS procedure they will be seated in a comfortable chair with hands placed on a pillow on the lap Small electrodes-soft strips that stick to the skin-will be placed on the skin to record the electrical activity of some muscles in the neck that are activated by the stimulation from TMS In TMS there will be a wire coil held over the scalp A brief electrical current will be passed through the coil creating a magnetic pulse that stimulates the brain Patients will hear a click and may feel a pulling sensation on the skin under the coil There may be muscle twitches of the face arm or leg In addition patients may be asked to tense certain muscles slightly or perform other simple actions so that the coil can be positioned appropriately Patients will sometimes be asked to bite down and tap their teeth slightly for about 1-12 minutes at a time They will be asked to show the sensory trick The stimulation is usually not painful although sometimes strong contractions of the scalp muscles can cause discomfort or a headache Patients can ask to have the procedure discontinued at any time The testing session takes about 2 hours done on an outpatient basis
Patients ages 18 and older who have cervical dystonia with at least one effective trick and patients with no effective trick may be eligible for this study There will also be a control group of healthy participants
Participants will be asked to show the sensory trick and may be asked to be videotaped During the TMS procedure they will be seated in a comfortable chair with hands placed on a pillow on the lap Small electrodes-soft strips that stick to the skin-will be placed on the skin to record the electrical activity of some muscles in the neck that are activated by the stimulation from TMS In TMS there will be a wire coil held over the scalp A brief electrical current will be passed through the coil creating a magnetic pulse that stimulates the brain Patients will hear a click and may feel a pulling sensation on the skin under the coil There may be muscle twitches of the face arm or leg In addition patients may be asked to tense certain muscles slightly or perform other simple actions so that the coil can be positioned appropriately Patients will sometimes be asked to bite down and tap their teeth slightly for about 1-12 minutes at a time They will be asked to show the sensory trick The stimulation is usually not painful although sometimes strong contractions of the scalp muscles can cause discomfort or a headache Patients can ask to have the procedure discontinued at any time The testing session takes about 2 hours done on an outpatient basis
Detailed Description:
The purpose of this study is to investigate the mechanism of sensory tricks on surround inhibition in the motor cortex in focal dystonia Sensory tricks or Geste antagoniste are various manoeuvres used by dystonic patients to transiently diminish their spasms Many of these manoeuvres involve motor as well as sensory input and here we use the term tricks to refer to both phenomena Little is known of this unique feature that is an evidence for the abnormality of sensorimotor integration in focal dystonia The relief of dystonic symptoms by the application of tricks suggests its potential as a clue to the understanding of the yet unclear mechanism of dystonia There is evidence that surround inhibition a cortical phenomenon that functions to suppress unwanted movements in surrounding muscles during voluntary actions is impaired in dystonia Since tricks transiently relieve the dystonic symptoms we hypothesize that the mechanism of tricks is the normalization of surround inhibition which is defective in dystonia
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0041 | None | None | None |