Ignite Creation Date:
2024-05-05 @ 11:28 PM
Last Modification Date:
2024-10-26 @ 10:34 AM
Study NCT ID:
NCT01335425
Status:
COMPLETED
Last Update Posted:
2015-09-23
First Post:
2011-04-13
Brief Title:
The Rolandic EpilepsyESESLandau-Kleffner Syndrome and Correlation With Language Impairment Study
Sponsor:
Maastricht University Medical Center
Organization:
Maastricht University Medical Center
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2015-09
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
REL
Brief Summary:
In clinical practice language impairment is frequently reported in association with nocturnal epileptiform activity There is a spectrum of epileptic conditions that are characterized by nocturnal epileptiform activity From mild to severe this spectrum involves Rolandic epilepsy RE nocturnal frontal lobe epilepsy NFLE Landau-Kleffner syndrome LKS and electrical status epilepticus during slow wave sleep ESES The exact characteristic of the relationship between nocturnal epileptiform activity and language impairment is yet to be explored The investigators suggest that nocturnal epileptiform EEG discharges and nocturnal epileptic seizures during development will cause diseased neuronal networks that involve language The diseased neuronal networks are less efficient compared with normal neuronal networks
Objective Identification of a diseased neuronal network characteristic in children with nocturnal epileptiform activity which can explain language impairment in these children For this the investigators will use functional magnetic resonance imaging MRI to analyse brain activity and diffusion weighted MRI to investigate white matter connectivity
Objective Identification of a diseased neuronal network characteristic in children with nocturnal epileptiform activity which can explain language impairment in these children For this the investigators will use functional magnetic resonance imaging MRI to analyse brain activity and diffusion weighted MRI to investigate white matter connectivity
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None