Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00073242
Status:
UNKNOWN
Last Update Posted:
2015-06-04
First Post:
2003-11-18
Brief Title:
Low-Dose Leptin and the Formerly-Obese
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
Effects of Low-Dose Leptin on the MetabolicBehavioral Phenotypes of the Formerly-Obese
Status:
UNKNOWN
Status Verified Date:
2015-06
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Our previous studies have demonstrated that there is substantial metabolic opposition to the maintenance of an altered body weight Leptin is a protein secreted by fat cells and the circulating concentrations of leptin are directly proportional to fat mass Leptin-deficiency is associated with severe obesity in rodents and in humans and the obesity is relieved by leptin administration These studies examine the hypothesis that some of this metabolic opposition cto the maintenance of an altered body weight can be relieved by restoring circulating concentrations of the hormone leptin to the same range as at usual body weight in subjects who are maintaining a reduced body weight The basic design of this study is to observe subjects at a 10 reduced body weight and then again at that reduced body weight while receiving physiological leptin or T3 supplementation
Detailed Description:
We demonstrated a substantial metabolic resistance to maintenance of altered body weight Leptin is secreted by fat cells in circulating concentrations that are directly proportional to fat mass Leptin-deficiency is associated with severe obesity in rodents and in humans and the obesity is relieved by leptin administration These studies examine the hypothesis that some of this metabolic opposition cto the maintenance of an altered body weight can be relieved by restoring circulating concentrations of the hormone leptin to the same range as at usual body weight in subjects who are maintaining a reduced body weight The basic design of this study is to observe subjects at a 10 reduced body weight and then again at that reduced body weight while receiving physiological leptin or T3 supplementation
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None