Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00076739
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-02-02
Brief Title:
Study of Brain Function During Cognitive Tasks
Sponsor:
National Institute of Neurological Disorders and Stroke NINDS
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Examining Associative Relations in Structured Event Complexes Using Functional Neuroimaging
Status:
COMPLETED
Status Verified Date:
2011-12-12
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to examine which areas of the brain are involved in performing certain cognitive tasks MRI uses a strong magnetic field and radio waves to produce images of body tissues and organs that provide information about structure and function of tissues
Healthy normal volunteers between 21 and 40 years of age may be eligible for this study Candidates must be native English speakers and must be right-handed They must have no history of nervous system disease or psychiatric disorder Candidates are screened with questionnaires and a neurological examination
Participants undergo functional MRI scanning For this procedure the subject lies on a stretcher that moves into the scanner - a metal cylinder surrounded by a strong magnetic field During the scan he or she is asked to make various decisions about whether words are related or not Two words are presented visually separated by a variable time delay The subject reads both words decides as quickly and accurately as possible whether the two words are related or not and indicates the answer by pressing a button The test takes about 2 hours When it is completed the subject completes a written questionnaire concerning his or her experience in the scanner
Healthy normal volunteers between 21 and 40 years of age may be eligible for this study Candidates must be native English speakers and must be right-handed They must have no history of nervous system disease or psychiatric disorder Candidates are screened with questionnaires and a neurological examination
Participants undergo functional MRI scanning For this procedure the subject lies on a stretcher that moves into the scanner - a metal cylinder surrounded by a strong magnetic field During the scan he or she is asked to make various decisions about whether words are related or not Two words are presented visually separated by a variable time delay The subject reads both words decides as quickly and accurately as possible whether the two words are related or not and indicates the answer by pressing a button The test takes about 2 hours When it is completed the subject completes a written questionnaire concerning his or her experience in the scanner
Detailed Description:
Objective The purpose of the protocol is to extend the structured event complex SEC model developed by the principal investigator Grafman Grafman 1995 proposed that action sequences are represented in form of SECs in the human prefrontal cortex PFC An SEC is a goal-oriented set of events that is sequentially structured and represents thematic knowledge morals abstractions concepts social rules event features event boundaries and grammars There are both temporal and semantic associative relations between subcomponents of SEC knowledge We will investigate hypotheses regarding the role of different regions within the PFC in processing associative relations We will also investigate how SECs differing in psychological dimensions such as temporal duration complexity and familiarity are represented and activated in the PFC We will further examine the temporal and semantic organization of SEC subcomponents by investigating how the goal and outcome structure of event knowledge is represented and activated in the PFC Further we will investigate how the temporal location of events within SECs are represented and activated in the PFC We will also investigate how goals and outcomes specifying the temporal order and duration of SEC subcomponents are processed within the PFC Additional objectives are to 1 investigate the neural representation of human emotions and decision-making based on utility estimation 2 investigate the relationships between cognitive and neural substrates of moral emotions and judgment Moll et al 2002a Moll et al 2002b with those of the SEC model developed by the principal investigator Grafman 1995 and 3 probe a new construct of cognitive dimensions incorporating critical explanatory variables in social cognition such as moral emotions and social event knowledge
Study Population In nineteen separate studies healthy normal adult volunteers will participate in experiments dealing with different kinds of associative relations in SECs using functional magnetic resonance imaging fMRI
Design The experiments we are conducting will employ within-subject rapid event-related fMRI designs to determine whether different types of SEC associative and other types of relations are stored in dissociable networks in the PFC In nineteen experiments we hope to automatically activate lexical event-based and temporally-based associative and other types of relations in SECs
Outcome Measures The data collected will consist of accuracy and response time measures of cognitive performance reflecting automatic priming of associative relations and fMRI activation images corresponding to each kind of associative relation and accuracy and response time measures of cognitive performance reflecting how temporal duration complexity and familiarity are represented and activated Experiments 10 and 11 will also record donation choices made by the subjects The results gained from this protocol will provide further evidence for modifying supporting or rejecting aspects of the SEC model and will provide further evidence for modifying supporting or rejecting aspects of a framework of social cognition such as moral behavior and social event knowledge
Study Population In nineteen separate studies healthy normal adult volunteers will participate in experiments dealing with different kinds of associative relations in SECs using functional magnetic resonance imaging fMRI
Design The experiments we are conducting will employ within-subject rapid event-related fMRI designs to determine whether different types of SEC associative and other types of relations are stored in dissociable networks in the PFC In nineteen experiments we hope to automatically activate lexical event-based and temporally-based associative and other types of relations in SECs
Outcome Measures The data collected will consist of accuracy and response time measures of cognitive performance reflecting automatic priming of associative relations and fMRI activation images corresponding to each kind of associative relation and accuracy and response time measures of cognitive performance reflecting how temporal duration complexity and familiarity are represented and activated Experiments 10 and 11 will also record donation choices made by the subjects The results gained from this protocol will provide further evidence for modifying supporting or rejecting aspects of the SEC model and will provide further evidence for modifying supporting or rejecting aspects of a framework of social cognition such as moral behavior and social event knowledge
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-N-0113 | None | None | None |