Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00078429
Status:
COMPLETED
Last Update Posted:
2008-07-24
First Post:
2004-02-25
Brief Title:
Molecular Epidemiology of Myocardial Infarction and Stroke in Older Adults - Ancillary to CHS
Sponsor:
National Heart Lung and Blood Institute NHLBI
Organization:
National Heart Lung and Blood Institute NHLBI
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2008-07
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
To investigation the association of thrombosis and inflammation genes with sub-clinical cardiovascular disease and with incident myocardial infarction and stroke in older adults
Detailed Description:
DESIGN NARRATIVE
The study represents a collaborative effort among investigators of the Cardiovascular Health Research Unit Department of Genome Sciences at the University of Washington UW and the multi-center Cardiovascular Health Study CHS including the CHS Blood Laboratory at the University of Vermont The study links advances in thrombosis and inflammation biology large-scale human genomics and population and statistical genetics with the unique resources of CHS a large bi-racial cohort of older adults In older men and women without clinically apparent vascular disease carotid intimal-medial thickness or IMT a measure of subclinical atherosclerosis C-reactive protein a sensitive marker of inflammation and D-dimer a global marker of activation of the hemostatic system predict subsequent clinical events such as myocardial infarction MI and stroke While the therapeutic benefits of thrombolytic therapy and aspirin suggest a major role for clotting and inflammation in the etiology of coronary disease and stroke the genetic determinants of these risk factors which are also influenced by traditional lifestyle risk factors such as smoking and obesity remain largely unexplored in older adults The setting for this study is the Cardiovascular Health Study a cohort study of 5888 older adults designed to assess risk factors for stroke and coronary disease Data on traditional risk factors on measures of subclinical disease and cardiovascular events are available to the ancillary study By integrating recent clinical and experimental data on age-related and vascular bed-specific regulation of blood coagulation and incorporating complete human genomic DNA sequence variation data from the NHLBI-funded UW Program for Genomic Applications the investigators will evaluate thoroughly the association of thrombosis and inflammation genes with 1 carotid IMT CRP and D-dimer levels measured at baseline and 2 incident MI and stroke in adults 65 years old followed for up to 12 years
The study represents a collaborative effort among investigators of the Cardiovascular Health Research Unit Department of Genome Sciences at the University of Washington UW and the multi-center Cardiovascular Health Study CHS including the CHS Blood Laboratory at the University of Vermont The study links advances in thrombosis and inflammation biology large-scale human genomics and population and statistical genetics with the unique resources of CHS a large bi-racial cohort of older adults In older men and women without clinically apparent vascular disease carotid intimal-medial thickness or IMT a measure of subclinical atherosclerosis C-reactive protein a sensitive marker of inflammation and D-dimer a global marker of activation of the hemostatic system predict subsequent clinical events such as myocardial infarction MI and stroke While the therapeutic benefits of thrombolytic therapy and aspirin suggest a major role for clotting and inflammation in the etiology of coronary disease and stroke the genetic determinants of these risk factors which are also influenced by traditional lifestyle risk factors such as smoking and obesity remain largely unexplored in older adults The setting for this study is the Cardiovascular Health Study a cohort study of 5888 older adults designed to assess risk factors for stroke and coronary disease Data on traditional risk factors on measures of subclinical disease and cardiovascular events are available to the ancillary study By integrating recent clinical and experimental data on age-related and vascular bed-specific regulation of blood coagulation and incorporating complete human genomic DNA sequence variation data from the NHLBI-funded UW Program for Genomic Applications the investigators will evaluate thoroughly the association of thrombosis and inflammation genes with 1 carotid IMT CRP and D-dimer levels measured at baseline and 2 incident MI and stroke in adults 65 years old followed for up to 12 years
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?: