Ignite Creation Date:
2024-05-05 @ 11:22 PM
Last Modification Date:
2024-10-26 @ 10:32 AM
Study NCT ID:
NCT01312207
Status:
UNKNOWN
Last Update Posted:
2011-03-10
First Post:
2011-03-08
Brief Title:
Macular Tractional Retinoschisis in Proliferative Diabetic Retinopathy
Sponsor:
National Taiwan University Hospital
Organization:
National Taiwan University Hospital
Study Overview
Official Title:
Macular Tractional Retinoschisis in Proliferative Diabetic Retinopathy
Status:
UNKNOWN
Status Verified Date:
2011-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Objective To evaluate the clinical manifestations and surgical prognosis of macular tractional retinoschisis in proliferative diabetic retinopathy
Design Retrospective case series Participants Cases with macular tractional retinoschisis with or without combined traction detachment TRD in proliferative diabetic retinopathy confirmed by optical coherence tomography OCT at a single institution between January 2007 and August 2010
Methods Cases were divided into two groups Group A had tractional retinoschisis only while Group B had TRD with retinoschisis of the elevated retina Clinical data including OCT findings were recorded and analyzed
Main Outcome Measures Demographic data clinical pictures surgical results and OCT findings will be compared between two the groups
Design Retrospective case series Participants Cases with macular tractional retinoschisis with or without combined traction detachment TRD in proliferative diabetic retinopathy confirmed by optical coherence tomography OCT at a single institution between January 2007 and August 2010
Methods Cases were divided into two groups Group A had tractional retinoschisis only while Group B had TRD with retinoschisis of the elevated retina Clinical data including OCT findings were recorded and analyzed
Main Outcome Measures Demographic data clinical pictures surgical results and OCT findings will be compared between two the groups
Detailed Description:
Fibrovascular tissue induced macular elevation is an important cause of visual loss in proliferative diabetic retinopathy PDR There are two main types of macular elevations in PDR traction retinal detachment TRD and tractional retinoschisis These two conditions may coexist either in the form of retinoschisis within the detached retina or predominantly retinoschisis with a small subfoveal fluid pocket Optical coherence tomography OCT studies have shown that in tractional retinoschisis the inner retinal layer is normal reflective outer layer is less reflective but not optically empty Bridging columnar tissues are frequently observed between the inner and outer layers Histopathological study by Faulborn et al showed adherence of posterior hyaloid membrane to the retina plus vitreous body shrinkage might induce retinal elevation with splitting of the outer plexiform layer leading to retinoschisis The bridging columnar tissues between inner and outer layers of the split retina mainly consisted of Muller cells Although tractional retinoschisis with or without retinal detachment has been suggested as the most frequent pattern of tractional macular elevation in eyes with proliferative diabetic retinopathy1 and peripheral retinoschisis are frequently found during operation for complications of PDR studies on clinical manifestations and post-operative visual prognosis of macular traction schisis are limited Lincoff reported a relatively good prognosis in eyes with tractional retinoschisis after vitrectomy No other large series specifically aimed at this entity can be found
In this report we will retrospectively study the clinical pictures of tractional retinoschisis on the macula Morphological changes and functional outcomes after surgery will be discussed Correlations between visual acuity and specific findings on color fundus pictures and OCT will be evaluated We will also analyze different behaviors of schisis only and combined tractional retinal detachment with schisis
In this report we will retrospectively study the clinical pictures of tractional retinoschisis on the macula Morphological changes and functional outcomes after surgery will be discussed Correlations between visual acuity and specific findings on color fundus pictures and OCT will be evaluated We will also analyze different behaviors of schisis only and combined tractional retinal detachment with schisis
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None