Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00076505
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-01-23
Brief Title:
Cell Studies of Parkinsons Disease
Sponsor:
National Human Genome Research Institute NHGRI
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Bioenergetic Function in Parkinsons Disease
Status:
COMPLETED
Status Verified Date:
2006-11-30
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine and compare blood samples from healthy volunteers and patients with Parkinsons disease to identify abnormalities associated with Parkinsons disease Disease symptoms include slowness of movement hand or leg shaking and stiffness Some patients have difficulty with balance Information from this study may provide information on how Parkinsons disease affects the brain and body and may help lead to a test for earlier diagnosis
Healthy volunteers and patients with Parkinsons disease who are 18 years of age or older may enroll in this study Participants will undergo the following procedures
Physical examination including evaluation of strength feeling coordination and balance
Blood drawing 150 milliliters about 10 tablespoons of blood will be drawn
Personal and family medical history
Consent to access medical records for research purposes
Blood samples will be examined for
Genetic analysis
Study of specific proteins and lipids
Study of mitochondria parts of cells that make energy
Healthy volunteers and patients with Parkinsons disease who are 18 years of age or older may enroll in this study Participants will undergo the following procedures
Physical examination including evaluation of strength feeling coordination and balance
Blood drawing 150 milliliters about 10 tablespoons of blood will be drawn
Personal and family medical history
Consent to access medical records for research purposes
Blood samples will be examined for
Genetic analysis
Study of specific proteins and lipids
Study of mitochondria parts of cells that make energy
Detailed Description:
This study wants to focus on mitochondrial defects associated with Parkinsons disease PD and how they relate to alpha-synuclein SNCA expression and function Individuals from families with inherited Parkinsons disease affected and at risk members as well as normal individuals will be enrolled All subjects will be asked to provide blood samples in order to study bioenergetic function in mitochondria from their platelets These studies will include genotyping and determination of polymorphisms in the subjects mitochondrial DNA mtDNA in order to delineate any significant abnormality that may be associated with a particular group Cardiolipin levels will be obtained fee for service at Lipomics Basic respirometry enzyme activity and somatic cell hybridization will be performed in the PIs lab Protein analysis will be performed in the proteomics facility at NIMH
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-HG-0092 | None | None | None |