Ignite Creation Date:
2024-05-05 @ 11:33 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00073268
Status:
COMPLETED
Last Update Posted:
2010-01-15
First Post:
2003-11-18
Brief Title:
Prevention of Type 2 Diabetes Mellitus in Children
Sponsor:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Organization:
National Institute of Diabetes and Digestive and Kidney Diseases NIDDK
Study Overview
Official Title:
Prevention of Type 2 Diabetes Mellitus in Children
Status:
COMPLETED
Status Verified Date:
2010-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This is a pilot study to examine the short-term effects of supervised exercise on metabolic risk factors for type 2 diabetes mellitus in children from a population that is at high risk for this disease We hypothesize that exercise will significantly improve insulin sensitivity in all children especially in children who are already insulin resistant thereby lowering the risk that they will go on to develop type 2 diabetes mellitus The specific hypotheses being tested are
1 Insulin resistance will be most evident in overweight children while an impaired ability of the pancreas to release insulin will be most evident in children with a family history of type 2 diabetes mellitus
2 Exercise will significantly improve insulin resistance as measured by the fasting glucoseinsulin ratio with little or no effect on insulin secretory capacity as measured by circulating insulin concentration at 1 3 and 5 minutes following an intravenous glucose load in children
3 Participation in a school-based health nutrition and exercise education program will have long-term beneficial effects on health-related behaviors and on insulin resistance
1 Insulin resistance will be most evident in overweight children while an impaired ability of the pancreas to release insulin will be most evident in children with a family history of type 2 diabetes mellitus
2 Exercise will significantly improve insulin resistance as measured by the fasting glucoseinsulin ratio with little or no effect on insulin secretory capacity as measured by circulating insulin concentration at 1 3 and 5 minutes following an intravenous glucose load in children
3 Participation in a school-based health nutrition and exercise education program will have long-term beneficial effects on health-related behaviors and on insulin resistance
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None