Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:02 AM
Study NCT ID:
NCT00001719
Status:
COMPLETED
Last Update Posted:
2008-03-04
First Post:
1999-11-03
Brief Title:
Magnetic Resonance Imaging of Blood Flow in the Liver and Abdomen
Sponsor:
National Institutes of Health Clinical Center CC
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
Examination of the Hemodynamics of the Portal Venous System in Normal Volunteers Using Magnetic Resonance Imaging
Status:
COMPLETED
Status Verified Date:
2002-08
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will use magnetic resonance imaging MRI to examine blood flow patterns in the arteries and veins of the liver and abdomen It will 1 determine the best way to measure blood flow in these vessels and 2 make detailed measurements of the blood flow patterns of these vessels Information about normal liver blood flow may help explain the role of blood flow in liver disease
Normal healthy volunteers 18 years of age and older may be eligible for this study They will undergo MRI-a diagnostic tool that uses a strong magnetic field and radio waves to show structural and chemical changes in tissue and the speed of moving blood The patient lies on a stretcher inside a metal cylinder the scanner for 1 to 15 hours and will be required to lie very still for 10 to 15 minutes at a time Blood pressure heart rate breathing and the amount of oxygen in the fingertip are measured during the scan
Normal healthy volunteers 18 years of age and older may be eligible for this study They will undergo MRI-a diagnostic tool that uses a strong magnetic field and radio waves to show structural and chemical changes in tissue and the speed of moving blood The patient lies on a stretcher inside a metal cylinder the scanner for 1 to 15 hours and will be required to lie very still for 10 to 15 minutes at a time Blood pressure heart rate breathing and the amount of oxygen in the fingertip are measured during the scan
Detailed Description:
The involvement of the liver by certain disease processes is non-uniform and may be related to hepatic anatomy and the dynamics of portal blood flow These differences may result from inhomogeneous delivery of hepatic toxins or trophic substances tumor secretion products or tumor metastases to different portions of the liver In addition to effects on the natural history of hepatic disease these features may affect the performance planningmethods and interpretation of diagnostic studies such as hepatic venous sampling for measurement of tumor secretion products This study will combine non-invasive quantitative in vivo measurements of blood flow with in vitro modeling of the vascular system The purpose of the study is to define the normal hemodynamics of hepatic blood flow particularly portal flow using Magnetic Resonance Angiography MRA and to draw inferences regarding the role of hemodynamics in the natural history of hepatic disease
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 98-CC-0148 | None | None | None |