Ignite Creation Date:
2024-05-05 @ 11:18 PM
Last Modification Date:
2024-10-26 @ 10:32 AM
Study NCT ID:
NCT01306526
Status:
COMPLETED
Last Update Posted:
2014-01-09
First Post:
2011-03-01
Brief Title:
Relationship Between Obstructive Sleep Apnea and Coronary Atherosclerosis
Sponsor:
National University of Singapore
Organization:
National University of Singapore
Study Overview
Official Title:
Intravascular Ultrasound Diagnostic Evaluation of Atherosclerosis in Singapore- Obstructive Sleep Apnea IDEAS-OSA Study
Status:
COMPLETED
Status Verified Date:
2014-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
IDEAS-OSA
Brief Summary:
Obstructive sleep apnea OSA is a respiratory disorder of sleep characterized by recurrent episodes of complete or partial upper airway obstruction leading to intermittent oxygen deprivation This results in sympathetic activation and surges in blood pressure production of vasoactive substances as well as activation of the inflammatory and procoagulant pathways Epidemiological evidence indicates the prevalence of OSA is higher in patients with coronary artery disease than in the general population The investigators recently showed that 657 and 419 of the Singapore patients admitted with myocardial infarction were found to have previously undiagnosed OSA and severe OSA respectively In a 10-year follow-up epidemiological study OSA was independently associated with a higher prevalence of fatal and non-fatal cardiovascular events among the otherwise healthy general population The investigators further showed that in patients who have undergone primary percutaneous coronary intervention for acute myocardial infarction OSA was an independent predictor of future adverse event rates Despite the observed association between OSA and adverse cardiovascular outcomes the underlying pathophysiological mechanisms remain unclear In this proposal the investigators aim to elucidate the relationship between OSA and composition of coronary atherosclerotic plaques
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None