Ignite Creation Date:
2024-05-05 @ 11:18 PM
Last Modification Date:
2024-10-26 @ 10:31 AM
Study NCT ID:
NCT01292902
Status:
COMPLETED
Last Update Posted:
2011-02-10
First Post:
2011-02-09
Brief Title:
Regional Distribution of Ventilation in Patients With Chronic Heart Failure
Sponsor:
Universidade Federal de Pernambuco
Organization:
Universidade Federal de Pernambuco
Study Overview
Official Title:
None
Status:
COMPLETED
Status Verified Date:
2011-01
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
Inspiratory muscle dysfunction is a reduction in the ability to generate pressure and force by the inspiratory muscles This decrease in the strength of these muscles can be attributed to biochemical and histological changes Some patients with CHF showed a reduction of maximal inspiratory pressure MIP and inspiratory muscle endurance and such factors known to exercise limitation and deterioration in quality of life and worsens the prognosis of these patients This study aims to evaluate the Regional pulmonary distribution volume and the influence of enclosures system thoracoabdominal in CHF patients with cardiomegaly associated with diaphragmatic weakness during quiet breathing and during exercise for inspiratory muscle and its correlation with functional data The investigators evaluated a total of 31 individuals divided into two groups CHF and control In the control group twelve volunteers participated with similar age gender and body mass index in relation to the group of patients with CHF The control group participants had an ejection fraction of left ventricle EF 50 without cardiac abnormalities of the cameras and MIP over 80 of predicted To conduct the exercise to the inspiratory muscles EMI was used for IMT Threshold device Threshold Inspiratory Muscle Trainer HealthScan Products Inc Cedar Grove New Jersey is one of the most used for training of inspiratory muscles in patients with several pathologies such as CHF The exercise time was 3 minutes During this period participants were encouraged to only breathe through the mouth and maintain a respiratory rate between 12 and 16ipm Opto-electronic plethysmography measures the volume changes of thoracoabdominal system by placing 89 markers formed by hemiesferas covered with retro-reflective paper taking the place of each of these hemiesferas determined by anatomical landmarks on the anterior and posterior regions of the chest and abdomen According to our study a lower ventilation on diaphragmatic region would lead to an increased perception of dyspnea during submaximal exercise in this population Moreover the observed changes in the pattern of regional distribution of ventilation in CHF patients compared to healthy individuals can serve as a basis for prospective cohort studies using IMT
Detailed Description:
None
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None