Ignite Creation Date:
2024-05-05 @ 10:00 AM
Last Modification Date:
2024-10-26 @ 9:05 AM
Study NCT ID:
NCT00006199
Status:
UNKNOWN
Last Update Posted:
2005-06-24
First Post:
2000-09-09
Brief Title:
Study of the Farnesyl Transferase Inhibitor R115777 in Combination With Topotecan NYU 99-32
Sponsor:
National Center for Research Resources NCRR
Organization:
National Center for Research Resources NCRR
Study Overview
Official Title:
None
Status:
UNKNOWN
Status Verified Date:
2004-01
Last Known Status:
RECRUITING
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
The purpose of this clinical trial is to establish the safest doses for the combination of a farnesyl transferase inhibitor R115777 plus topotecan in patients with advanced solid tumors previously treated or beyond standard therapy of clinical benefit Maximum tolerated dose dose limiting toxicity and the activity of this combination will be assessed
This chemotherapy regimen is a two-pronged attack at the way cancer cells replicate R115777 is a compound that may inhibit cancer cell growth by interfering with the p21 ras oncogene while topotecan a topoisomerase-1 inhibitor works on cancer cells not subject to control by the ras oncogene Animal studies suggest that the combination may be synergistic Another advantage is that R115777 can be taken by mouth
This chemotherapy regimen is a two-pronged attack at the way cancer cells replicate R115777 is a compound that may inhibit cancer cell growth by interfering with the p21 ras oncogene while topotecan a topoisomerase-1 inhibitor works on cancer cells not subject to control by the ras oncogene Animal studies suggest that the combination may be synergistic Another advantage is that R115777 can be taken by mouth
Detailed Description:
None
Study Oversight
Has Oversight DMC:
Is a FDA Regulated Drug?:
Is a FDA Regulated Device?:
Is an Unapproved Device?:
Is a PPSD?:
Is a US Export?:
Is an FDA AA801 Violation?:
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| M01RR000096 | NIH | None | httpsreporternihgovquickSearchM01RR000096 |