Ignite Creation Date:
2024-05-05 @ 11:32 AM
Last Modification Date:
2024-10-26 @ 9:09 AM
Study NCT ID:
NCT00075296
Status:
COMPLETED
Last Update Posted:
2017-07-02
First Post:
2004-01-08
Brief Title:
FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression
Sponsor:
National Institute of Mental Health NIMH
Organization:
National Institutes of Health Clinical Center CC
Study Overview
Official Title:
FMRI Study of Performance During a Probabilistic Reversal Learning Task in Depression
Status:
COMPLETED
Status Verified Date:
2008-04-21
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
None
Brief Summary:
This study will examine how the brains of depressed people function during learning and respond to feedback Participants perform a probabilistic reversal learning task to determine whether depressed people perform worse on a task than non-depressed people when they sometimes receive misleading negative feedback
Right-handed healthy volunteers people with major depression who are currently depressed or have previously been depressed and people with bipolar depression between 18 and 50 years of age may be eligible for this study Candidates are screened with a medical and psychiatric history physical examination electrocardiogram blood and urine tests They are also interviewed to evaluate mood sleep energy work and school performance and social relationships and asked to answer questions to investigate whether any history of paranoia panic attacks obsession compulsions suicidal thoughts eating disturbances and alcohol or drug abuse is present They complete rating scales for depression anxiety and negative thinking history of alcohol and tobacco use physical movement socioeconomic status overall level of functioning and depression type Finally they undergo a battery of neuropsychological tests to assess general intelligence handedness and specific cognitive abilities including memory and concentration
Participants perform the probabilistic reversal learning task either in a testing room seated in front of a computer or lying down while undergoing functional magnetic resonance imaging FMRI FMRI is a diagnostic test that uses a strong magnet and radio waves to obtain pictures of brain structure and function For the scan the subject lies on a narrow bed with a plastic-encased metal coil close to the head The bed slides into the scanner - a small tunnel about 6 feet long All subjects whether in the testing room or in the MRI scanner undergo the learning task as follows
Two patterns are presented on a computer screen One pattern is designated correct and the other incorrect Subjects are asked to choose the correct pattern on each try and are provided feedback as to whether the response was right or wrong Sometimes the rule changes and the pattern that was correct is now wrong and vice versa so that the new correct pattern must be chosen In addition misleading feedback is sometimes given intentionally indicating the subject chose the wrong pattern when in fact the response was correct Subjects should change their response only when they are sure that the rule has changed and not because they were incorrectly told that they were wrong For patients undergoing MRI blood flow in the different areas of the brain is measured during the test
After the test outside the scanner participants undergo additional tests of attention memory and concentration like those that were administered during the screening procedures
Right-handed healthy volunteers people with major depression who are currently depressed or have previously been depressed and people with bipolar depression between 18 and 50 years of age may be eligible for this study Candidates are screened with a medical and psychiatric history physical examination electrocardiogram blood and urine tests They are also interviewed to evaluate mood sleep energy work and school performance and social relationships and asked to answer questions to investigate whether any history of paranoia panic attacks obsession compulsions suicidal thoughts eating disturbances and alcohol or drug abuse is present They complete rating scales for depression anxiety and negative thinking history of alcohol and tobacco use physical movement socioeconomic status overall level of functioning and depression type Finally they undergo a battery of neuropsychological tests to assess general intelligence handedness and specific cognitive abilities including memory and concentration
Participants perform the probabilistic reversal learning task either in a testing room seated in front of a computer or lying down while undergoing functional magnetic resonance imaging FMRI FMRI is a diagnostic test that uses a strong magnet and radio waves to obtain pictures of brain structure and function For the scan the subject lies on a narrow bed with a plastic-encased metal coil close to the head The bed slides into the scanner - a small tunnel about 6 feet long All subjects whether in the testing room or in the MRI scanner undergo the learning task as follows
Two patterns are presented on a computer screen One pattern is designated correct and the other incorrect Subjects are asked to choose the correct pattern on each try and are provided feedback as to whether the response was right or wrong Sometimes the rule changes and the pattern that was correct is now wrong and vice versa so that the new correct pattern must be chosen In addition misleading feedback is sometimes given intentionally indicating the subject chose the wrong pattern when in fact the response was correct Subjects should change their response only when they are sure that the rule has changed and not because they were incorrectly told that they were wrong For patients undergoing MRI blood flow in the different areas of the brain is measured during the test
After the test outside the scanner participants undergo additional tests of attention memory and concentration like those that were administered during the screening procedures
Detailed Description:
When depressed subjects perceive they have failed while performing a neuropsychological task their performance on subsequent trials becomes impaired Elliott et al showed that MDD subjects were far more likely to fail on subsequent tasks after failure on one task than controls This effect has been described as an abnormal response to negative feedback or a catastrophic response to perceived failure
Murphy et al investigated this further using a probabilistic reversal learning task in which subjects were faced with occasional negative feedback that was actually false On each trial of the task subjects choose one of two stimuli on screen one considered correct and the other incorrect this is followed by feedback Instructions prior to starting the task inform the subject that sometimes the rule will change and the previously correct stimulus will be incorrect but sometimes the computer will give them incorrect feedback They are instructed to switch responding only when they are sure the rule has actually changed MDD subjects demonstrate intact acquisition and reversal of probabilistic learning but are impaired in their ability to maintain a response in the face of misleading negative feedback This profile of impairment may be relatively specific to MDD as for example it is not found in subjects with other neuropsychiatric conditions This abnormal response to negative feedback may represent a significant link between negative affect and cognitive impairments in depression
During the proposed study functional magnetic resonance images will be acquired while subjects perform a version of the probabilistic reversal learning task Four groups will take part MDD bipolar depressed unmedicated MDD in remission and healthy control subjects These images will be used to investigate differences in neural activation between the four groups to clarify whether this specific profile of behavioral response extends to bipolar depressed subjects and to assess the mood state dependences of this effect This would increase understanding of the specific profile of performance on this task and neural basis of this abnormal response to negative feedback that contributes to impairment of cognitive performance in depression
Murphy et al investigated this further using a probabilistic reversal learning task in which subjects were faced with occasional negative feedback that was actually false On each trial of the task subjects choose one of two stimuli on screen one considered correct and the other incorrect this is followed by feedback Instructions prior to starting the task inform the subject that sometimes the rule will change and the previously correct stimulus will be incorrect but sometimes the computer will give them incorrect feedback They are instructed to switch responding only when they are sure the rule has actually changed MDD subjects demonstrate intact acquisition and reversal of probabilistic learning but are impaired in their ability to maintain a response in the face of misleading negative feedback This profile of impairment may be relatively specific to MDD as for example it is not found in subjects with other neuropsychiatric conditions This abnormal response to negative feedback may represent a significant link between negative affect and cognitive impairments in depression
During the proposed study functional magnetic resonance images will be acquired while subjects perform a version of the probabilistic reversal learning task Four groups will take part MDD bipolar depressed unmedicated MDD in remission and healthy control subjects These images will be used to investigate differences in neural activation between the four groups to clarify whether this specific profile of behavioral response extends to bipolar depressed subjects and to assess the mood state dependences of this effect This would increase understanding of the specific profile of performance on this task and neural basis of this abnormal response to negative feedback that contributes to impairment of cognitive performance in depression
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None
Secondary IDs
| Secondary ID | Type | Domain | Link |
|---|---|---|---|
| 04-M-0075 | None | None | None |