Ignite Creation Date:
2024-05-05 @ 11:12 PM
Last Modification Date:
2024-10-26 @ 10:30 AM
Study NCT ID:
NCT01278875
Status:
ACTIVE_NOT_RECRUITING
Last Update Posted:
2023-10-10
First Post:
2011-01-18
Brief Title:
Function of High Density Lipoproteins in Acute Coronary Syndromes
Sponsor:
McGill University Health CentreResearch Institute of the McGill University Health Centre
Organization:
McGill University Health CentreResearch Institute of the McGill University Health Centre
Study Overview
Official Title:
High Density Lipoprotein Function in Acute Coronary Syndromes
Status:
ACTIVE_NOT_RECRUITING
Status Verified Date:
2023-10
Last Known Status:
None
Delayed Posting:
No
If Stopped, Why?:
Not Stopped
Has Expanded Access:
False
If Expanded Access, NCT#:
N/A
Has Expanded Access, NCT# Status:
N/A
Acronym:
HDL_ACS
Brief Summary:
High density lipoproteins HDL have many effects that protect against cardiovascular diseases In an acute heart attack acute coronary syndrome -ACS HDL change in composition and structure reflecting the inflammatory environment that accompanies an ACS The investigators will examine the function of HDL during an ACS and again when the patient has recovered
Detailed Description:
High density lipoproteins HDL have pleiotropic effects associated with protection against atherosclerosis These effects include cellular cholesterol efflux anti-inflammatory and anti-oxidant effects increase in nitric acid NO production from vascular endothelial cells and differentiation of endothelial progenitor cells for repair at sites of vascular injury The measurement of the cholesterol mass within HDL HDL-C does not provide an adequate measure of HDL function The investigators therefore propose to test and validate biomarkers of HDL function in patients with acute coronary syndromes ACS
Hypothesis HDL lose their cardiovascular protective functions in ACS The investigators hypothesize that these changes are transient and partly normalize within 12 weeks In this proposal the investigators will examine the function of HDL in acute coronary syndromes ACS and 12 weeks later in the recovery phase Acute coronary syndromes are characterized by an acute inflammatory reaction a marked decrease in HDL in plasma and a shift of the HDL proteome to an inflammatory phenotype
Hypothesis HDL lose their cardiovascular protective functions in ACS The investigators hypothesize that these changes are transient and partly normalize within 12 weeks In this proposal the investigators will examine the function of HDL in acute coronary syndromes ACS and 12 weeks later in the recovery phase Acute coronary syndromes are characterized by an acute inflammatory reaction a marked decrease in HDL in plasma and a shift of the HDL proteome to an inflammatory phenotype
Study Oversight
Has Oversight DMC:
None
Is a FDA Regulated Drug?:
None
Is a FDA Regulated Device?:
None
Is an Unapproved Device?:
None
Is a PPSD?:
None
Is a US Export?:
None
Is an FDA AA801 Violation?:
None