Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:23 AM
Ignite Modification Date:
2025-12-25 @ 1:23 AM
NCT ID:
NCT00142493
Eligibility Criteria:
Inclusion Criteria:
* Healthy normal volunteers, age 18 to 50 years \*,who show no evidence of neurologic deficit on questionnaire and physical examination.
* Females must be non-pregnant as demonstrated using a serum pregnancy test.
* Right hand dominant.
* High school education or above.
* English as native language or equivalent degree of fluency. \*Age group selected based on pharmacokinetic models for drug infusion, and norms for standardized memory tests.
Exclusion Criteria:
* Any evidence of neurologic deficit including seizures, severe head trauma resulting in unconsciousness, or any previously abnormal study of CNS - (e.g. MRI, EEG, etc.)
* Any deficit in auditory or visual ability.
* Any history of hypertension (resting BP \>150 systolic, \>100 diastolic) or taking anti- hypertensive medication or cardiovascular disease.
* Significant pulmonary, renal, gastrointestinal, or endocrine metabolic disease which in the opinion of the investigator would complicate the goals of this study.
* Allergy to propofol or eggs.
* History of acute intermittent porphyria in subject or subject's blood relatives.
* History of substance abuse
* Currently taking centrally acting medications (e,g, benzodiazepines or anti depressants)
* Subjects whose body weight relative to their height exceeds accepted criteria for defining obesity in the general population (Body Mass Index \> 30). Excess weight can affect the pharmacodynamics of the drug in the body.
* Anyone who, in the opinion of the investigators, would be unwilling or unable to tolerate the procedures and/or comply with the task instructions.
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
50 Years
Study:
NCT00142493
Study Brief:
Protocol Section:
NCT00142493