Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:18 AM
Ignite Modification Date:
2025-12-25 @ 1:18 AM
NCT ID:
NCT00830193
Eligibility Criteria:
Inclusion Criteria:
* The investigators included critically ill adult patients at least 18 years of age who consented to participate in the trial, had central venous access and a foley catheter, required a contrast-enhanced CT of any organ system(s), and were considered 'at risk' for the development of CIN.
* The investigators defined 'at risk' to include patients with at least one of the following at the time of randomization (i) a serum creatinine of \> 106 µmol/L and or urea \> 6 mmol/L, (ii) urine output of \< 0.5 cc/kg over \> 4 hrs or (iii) an increase in serum creatinine of \> 50 µmol/L in \< 24 hours.
Exclusion Criteria:
* The investigators excluded patients with a
* CK \> 5,000 or the presence of myoglobinuria
* a known allergy or hypersensitivity reaction to radiographic contrast dye or NAC
* serious illness with imminent threat of dying (low likelihood of survival within 48-hours) or poor prognosis
* pregnancy
* patients with cardiogenic shock (NYHA class 3 or 4 symptoms)
* known or suspected nephritic, nephrotic or pulmonary-renal syndromes
* a post renal etiology of renal impairment
* previous renal transplant
* known solitary kidney
* serum creatinine \> 200 µmol/L or (xi) recent exposure to radiographic contrast within 14 days of randomization.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
16 Years
Study:
NCT00830193
Study Brief:
Protocol Section:
NCT00830193