Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:13 AM
Ignite Modification Date:
2025-12-25 @ 1:13 AM
NCT ID:
NCT04477993
Eligibility Criteria:
Inclusion Criteria:
* Patients hospitalized with SARS-CoV-2 pneumonia confirmed by RT-PCR or serology (IgA);
* PaO2/FiO2 \< 300 (not fully explained by heart failure or volume overload) or SpO2 \< 90% on room air.
Exclusion Criteria:
* Symptom onset \> 14 days;
* Neutrophil count \< 1,000/mm3;
* Platelets \< 50,000/mm3;
* ICU care at enrollment;
* On invasive mechanical ventilation at enrollment;
* Current use of experimental therapy for COVID-19 (except: azithromycin or corticosteroids)
* Uncontrolled arterial hypertension;
* Current or previous use of systemic immunosuppressive therapy in the last 30 days;
* Pregnancy or lactation;
* Estimated creatinine clearance \< 30 mL/min or receiving CRRT or intermittent hemodialysis;
* Allergy to ruxolitinib;
* Active tuberculosis;
* HIV seropositivity;
* Prior history of progressive multifocal leukoencephalopathy;
* Use of any JAK inhibitor in the last 30 days before study enrollment;
* Not qualifying according to investigators' perception.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
95 Years
Study:
NCT04477993
Study Brief:
Protocol Section:
NCT04477993