Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:10 AM
Ignite Modification Date:
2025-12-25 @ 1:10 AM
NCT ID:
NCT07144293
Eligibility Criteria:
Inclusion Criteria:
1. Must be an older person with confirmed diagnosis of HIV-1, defined as ≥ 50 years at study entry.
2. Must have been diagnosed with HIV at least 10 years ago, as confirmed by medical records or self-report.
3. Must be on a stable effective combination antiretroviral therapy (ART) regimen, with no changes in the regimen within 12 weeks before joining the study with 2 or more consecutive HIV-RNA levels \< 50 copies/mL within 48 weeks prior to study entry.
4. Must meet one or more Fried Frailty Phenotype criteria w/in 60 days prior to entry.
5. Must have eGFR \> 30 using CKD-EPI per 2021 calculation equation.
Exclusion Criteria:
1. Have used quercetin or dasatinib before.
2. Need to take medications that affect CYP3A4 or interact with dasatinib (e.g., certain HIV medications).
3. Have an active cancer (except non-melanoma skin cancer).
4. Have active liver disease with a Child Pugh score greater than 6, or other significant liver problems.
5. Are on dialysis or have had a kidney transplant.
6. Have had a heart attack, angina, stroke, or mini-stroke in the last 6 months.
7. Have a known history of pulmonary arterial hypertension or other respiratory disease requiring supplemental oxygen within 60 days before joining the study.
8. Have uncontrolled diabetes with an HgbA1c level greater than 8% within 60 days before joining the study.
9. Have substance use that might interfere with study participation, as determined by the site investigator.
10. Have had a significant illness within 60 days before joining the study.
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
50 Years
Study:
NCT07144293
Study Brief:
Protocol Section:
NCT07144293