Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 1:07 AM
Ignite Modification Date:
2025-12-25 @ 1:07 AM
NCT ID:
NCT01989793
Eligibility Criteria:
Inclusion Criteria:
* Age 70 and over
* Pre-frail as determined by frailty criteria
Exclusion Criteria:
* Under age 70
* Robust or frail by frailty criteria
* Have other indications for use of any angiotensin-receptor blockers (ARB) such as myocardial infarction in past year, history of congestive heart failure, uncontrolled hypertension
* Current use of ARBs or angiotensin-converting enzyme (ACE) inhibitors
* Prior allergic reaction to or hyperkalemia with losartan or any ARB
* Chronic renal failure with a glomerular filtration rate of \< 30
* Current daily use of non-steroidal anti-inflammatory agents
* Current use of steroids
* Lower extremity disability that would prevent muscle strength testing
* Echocardiogram-diagnosed cardiac failure as evidenced by left ventricular ejection fraction less than 50%
* Cognitive impairment with a Mini-Mental State Examination \< 24
Healthy Volunteers:
True
Sex:
ALL
Minimum Age:
70 Years
Maximum Age:
100 Years
Study:
NCT01989793
Study Brief:
Protocol Section:
NCT01989793