Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:56 AM
Ignite Modification Date:
2025-12-25 @ 12:56 AM
NCT ID:
NCT03861767
Eligibility Criteria:
UPMC REMAP
Inclusion Criteria:
* Adult patient evaluated pre-operatively for elective surgery at UPMC
* Minimum lead time before surgery to provide domain specific intervention (range 7-180 days pre-operatively)
* Age greater to or equal to 18 years of age
Exclusion Criteria:
* Death is deemed to be imminent or inevitable
* Emergency surgical procedure without suitable lead-in time
* Previous participation in this REMAP within the last 90 days, flagged by elective or emergency surgical encounter at UPMC in the past 90 days
SPRY Domain
Inclusion Criteria:
* Age \>= 60 years
* Age \< 60 but evidence of comorbidity risk as represented by a Charlson Comorbidity Index of \> 2 in 12 months prior to enrollment
* Able to take an oral medication in non-crushable pill form
* Women must be post-menopausal, which is defined as not having a menstrual period within the last 12 months
Exclusion Criteria:
* The treating clinician believes that participation in the domain would not be in the best interest of the patient
* Pre-existing diabetes type I or II
* Women of child-bearing potential
* Hospital stay \<24 hours
* Presently taking metformin or prior use in the past 6 months
* Evidence of an absolute or relative contraindication to Metformin therapy
* Known allergy to metformin
* Acute or chronic metabolic acidosis with or without coma
* Hemodialysis, end-stage renal disease, or Glomerular Filtration Rate (GFR) \< 45 in the prior 30 days
* Ongoing treatment with therapy known to have significant drug-drug interaction with metformin (carbonic anhydrase inhibitors, cimetidine, gliptins)
* History of lactic acidosis
* History of excessive alcohol intake
* Severe hepatic dysfunction
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Study:
NCT03861767
Study Brief:
Protocol Section:
NCT03861767