Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:54 AM
Ignite Modification Date:
2025-12-25 @ 12:54 AM
NCT ID:
NCT03566667
Eligibility Criteria:
Inclusion Criteria:
* A diagnosis of COPD confirmed by spirometry showing post bronchodilator value of Forced Expiratory Volume in one second (FEV1)//Forced Vital Capacity (FVC) \< 70 according to the Global Initiative on Obstructive Pulmonary Disease (GOLD)
* ≥40 years of age
* Sinus rhythm ≥50/min and \<120 at inclusion
Exclusion Criteria:
* Known hypersensitivity to metoprolol or related derivatives
* AV block II or III unless treated with a pacemaker
* Sinus bradycardia (resting heart rate \<50/min)
* Sick sinus syndrome unless treated with a pacemaker
* Atrial fibrillation/flutter
* Clinical signs of or a previous diagnosis of heart failure, angina pectoris, myocardial infarction, cerebrovascular disease or critical peripheral ischemia
* Systolic blood pressure \<90 mmHg
* Any tachy-arrythmias other than sinus rhythm
* Sinus tachycardia \>120 / min
* Systolic blood pressure \<90 mmHg
* Severe bronchial asthma
* Current beta-blocker treatment
* Inability to provide informed consent
* Age below 40 years
* Acute on-going exacerbation of COPD
* Previous randomization in the BRONCHIOLE trial
* Ongoing pregnancy (excluded by pregnancy test in fertile women)
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
40 Years
Study:
NCT03566667
Study Brief:
Protocol Section:
NCT03566667