Eligibility Module
The Eligibility Module contains detailed information about who can participate in the clinical trial. This includes eligibility criteria, age restrictions, gender requirements, healthy volunteer status, and study population descriptions, helping researchers understand who is eligible to participate in the study.
Eligibility Module path is as follows:
Study -> Protocol Section -> Eligibility Module
Eligibility Module
Ignite Creation Date:
2025-12-25 @ 12:41 AM
Ignite Modification Date:
2025-12-25 @ 12:41 AM
NCT ID:
NCT04912167
Eligibility Criteria:
Inclusion Criteria:
* Aged between 18 - 75 years old
* First-time ST-segment elevation myocardial infarction based on the newest ESC guidelines
* Timely primary percutaneous coronary intervention within 12 hours from onset
* Written informed consent acquired
Exclusion Criteria:
* Known history of or persistent clinical chronic heart failure prior to randomization
* Previous use of ARNI, or intolerance or contraindications to study drugs including ARNI or ACEI
* History of significant chronic coronary obstruction and adverse ventricular remodeling
* History of any cardiomyopathy, valvular heart disease, congenital heart disease, stent or CABG, or planned open-heart surgery within 3 months
* History of hepatic impairment or history of cirrhosis with evidence of portal hypertension
* History of chronic renal dysfunction, or eGFR \< 30 ml/min/1.73 m2
* History of malignancy and with a life span less than one year
* Patients with a known history of angioedema related to previous ACEIs/ARB therapy.
* With contraindication to MRI examination (pacemaker and claustrophobia) or cannot finish breath-holding when lying on the examination bed
* Pregnancy or nursing women
Healthy Volunteers:
False
Sex:
ALL
Minimum Age:
18 Years
Maximum Age:
75 Years
Study:
NCT04912167
Study Brief:
Protocol Section:
NCT04912167